BMAL1 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 9576906)
35

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		BMAL1	NPAS2
Description		basic helix-loop-helix ARNT like 1	neuronal PAS domain protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Chromatoid Body Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol CLOCK-BMAL Transcription Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Aryl Hydrocarbon Receptor Binding Sequence-specific DNA Binding Protein Dimerization Activity Hsp90 Protein Binding E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Response To Xenobiotic Stimulus Regulation Of Gene Expression Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Rhythmic Process Response To Redox State Positive Regulation Of Behavioral Fear Response
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31798171 31959993) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12	29 interacting genes: ARNT ARNT2 BMAL1 BPIFA1 CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1
Entrez ID		406	4862
HPRD ID		03973	09137
Ensembl ID		ENSG00000133794	ENSG00000170485
Uniprot IDs		A0A140VKD3 A0A669KBF4 B2RCL8 O00327	A2I2P5 Q99743
PDB IDs		4H10 8RW6 8RW8
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Transcription Regulator Complex Chromatin Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Transcription Coactivator Binding E-box Binding Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Photoperiodism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Protein Acetylation Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Circadian Rhythm Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hexose Biosynthetic Process Regulation Of Multicellular Organismal Process Nucleus Positive Regulation Of Metabolic Process Response To Radiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod	Chromatin Transcription Regulator Complex Intracellular Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Nuclear Receptor Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of DNA-templated Transcription Aryl Hydrocarbon Receptor Binding Regulation Of RNA Biosynthetic Process Aryl Hydrocarbon Receptor Complex Rhythmic Process Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor Activity DNA Binding Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Acetyltransferase Activity Hormone-mediated Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process
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