BMAL1 and AHR

Number of citations: 0 (PubMedID 9079689)
Data Source: HPRD (in vivo, two hybrid)

		BMAL1	AHR
Name		basic helix-loop-helix ARNT like 1	aryl hydrocarbon receptor
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Chromatoid Body Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Aryl Hydrocarbon Receptor Complex Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Aryl Hydrocarbon Receptor Binding Sequence-specific DNA Binding Protein Dimerization Activity Hsp90 Protein Binding E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation	Blood Vessel Development Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance Cellular Response To Molecule Of Bacterial Origin Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		None	Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-monoxime Resveratrol Quercetin Tapinarof beta-Naphthoflavone Emodin 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Diosmin Kynurenic Acid Epigallocatechin gallate Cantharidin Indirubin Carbendazim Indigo
GWAS		No GWAS studies recorded	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Bitter beverage consumption ( 31046077 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Caffeine consumption ( 21490707 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Coffee consumption ( 31046077 25288136 21357676 29367735 31345160 31959922 ) Coffee consumption (cups per day) ( 25288136 31837886 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 27424798 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Inflammatory bowel disease ( 26192919 ) Lung cancer in ever smokers ( 28604730 ) Metabolic traits ( 21886157 ) Microalbuminuria ( 31511532 ) Plasma kynurenine levels in major depressive disorder ( 29317604 ) Rosacea symptom severity ( 29771307 ) Severe influenza A (H1N1) infection ( 26379185 ) Sweet beverage consumption ( 31046077 ) Tea consumption ( 31046077 ) Triglyceride levels ( 32203549 ) Ulcerative colitis ( 26192919 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31630189 31511532 ) Urinary potassium excretion ( 31409800 ) Urinary sodium excretion ( 31409800 )
Novel Interactors		None recorded	1 novel interactors: GSDME
Interacting Genes		25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12	35 interacting genes: AIP AR ARNT ARNT2 BMAL1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 SRC STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		406	196
HPRD ID		03973	02596
Ensembl ID		ENSG00000133794	ENSG00000106546
Uniprot IDs		A0A140VKD3 A0A669KBF4 B2RCL8 O00327	P35869
PDB IDs		4H10 8RW6 8RW8	5NJ8 7ZUB 8QMO
GO Terms Enriched among Interactors		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Transcription Regulator Complex Chromatin Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Transcription Coactivator Binding E-box Binding Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Photoperiodism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Protein Acetylation Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Circadian Rhythm Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hexose Biosynthetic Process Regulation Of Multicellular Organismal Process Nucleus Positive Regulation Of Metabolic Process Response To Radiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod	Aryl Hydrocarbon Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II General Transcription Initiation Factor Activity MRNA Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Nucleus Nucleic Acid Metabolic Process MRNA Transcription Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Transcription Factor TFIID Complex DNA-binding Transcription Factor Binding Chromatin DNA-templated Transcription Initiation Nuclear Receptor Binding RNA Metabolic Process DNA Binding Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Intracellular Receptor Signaling Pathway Aryl Hydrocarbon Receptor Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coactivator Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II