ZMYND11 and EZH1

Number of citations of the paper that reports this interaction (PubMedID 16565076)
0

Data Source:
HPRD (in vivo)

		ZMYND11	EZH1
Description		zinc finger MYND-type containing 11	enhancer of zeste 1 polycomb repressive complex 2 subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K36me3 Reader Activity	DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Nucleosome Binding Histone Methyltransferase Activity Histone Binding Histone H3K27 Methyltransferase Activity Molecular Condensate Scaffold Activity Histone H3K27 Trimethyltransferase Activity
	Biological Process	Chromatin Organization Regulation Of Signal Transduction Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of JNK Cascade Defense Response To Virus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs			Tazemetostat
Diseases
GWAS		Malaria ( 31844061)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 31562340) Waist-hip index ( 34021172)
Interacting Genes		26 interacting genes: ARHGEF18 BMPR1A DYNLL1 E2F6 EMSY ETS2 EZH1 EZH2 H3-3A H3-4 H4C1 HDAC1 HOXD4 LTBR MAGEC2 MYB NCOR1 PDLIM7 SMAD2 SMAD3 SMARCA4 SRPK1 TAB1 TRAF3 TRAF6 ZHX1	3 interacting genes: E2F6 EED ZMYND11
Entrez ID		10771	2145
HPRD ID		09830	03397
Ensembl ID		ENSG00000015171	ENSG00000108799
Uniprot IDs		A0A0D9SGD6 A0A994J4C0 A0A994J4I8 A0A994J6Y5 B7Z2J6 E7ENI9 Q15326 Q5BJG6 Q5UGI2	A0A0A0MSY9 Q92800
PDB IDs		4NS5 5HDA	7KSO 7KSR 7KTP 7TD5
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Endoderm Development Regulation Of MiRNA Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Subtelomeric Heterochromatin Formation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Constitutive Heterochromatin Formation Chordate Embryonic Development Heterochromatin Formation Negative Regulation Of Androgen Receptor Signaling Pathway Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of MiRNA Metabolic Process Multicellular Organism Development Positive Regulation Of Transforming Growth Factor Beta Production RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Developmental Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Histone H3K27 Trimethyltransferase Activity Paraxial Mesoderm Morphogenesis Chromosome, Telomeric Region RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Pronucleus Sex Chromatin Histone H3K36me3 Reader Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Genomic Imprinting Regulation Of DNA-templated Transcription MLL1 Complex Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Epigenetic Programming Of Gene Expression Chromosome Nucleosome Binding Spinal Cord Development Negative Regulation Of JNK Cascade Chromatin Organization Regulation Of RNA Metabolic Process Oligodendrocyte Differentiation Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm
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