ZMYND11 and EZH1

Number of citations of the paper that reports this interaction (PMID 16565076)
5

Data Source:
HPRD (in vivo)

		ZMYND11	EZH1
Gene Name		zinc finger, MYND-type containing 11	enhancer of zeste 1 polycomb repressive complex 2 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Methylated Histone Binding	Chromatin Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Cycle Cell Proliferation Viral Process Chromatin Modification Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anatomical Structure Morphogenesis Histone H3-K27 Methylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: BMPR1A C11orf30 DYNLL1 E2F6 ETS2 EZH1 EZH2 H3F3A HDAC1 HOXD4 LTBR MAGEC2 MYB NCOR1 PDLIM7 SMAD2 SMAD3 SMARCA4 SRPK1 TAB1 TRAF3 TRAF6 ZHX1	3 interactors: E2F6 EED ZMYND11
Entrez ID		10771	2145
HPRD ID		09830	03397
Ensembl ID		ENSG00000015171	ENSG00000108799
Uniprot IDs		B7Z2J6 Q15326 Q5BJG6 Q5UGI2	Q92800
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process RNA Biosynthetic Process Gene Expression Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Nucleobase-containing Compound Metabolic Process Developmental Process Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Paraxial Mesoderm Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Chromosome Organization Cell Differentiation Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Gene Expression, Epigenetic Paraxial Mesoderm Development Transcription From RNA Polymerase II Promoter Chromatin Modification Response To Growth Factor Positive Regulation Of Signal Transduction Immune System Process Cellular Metabolic Process Positive Regulation Of Metabolic Process Multicellular Organismal Development Gene Silencing	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Chromatin Modification RNA Metabolic Process Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of JNK Cascade Genetic Imprinting Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Chromosome Organization Regulation Of Transcription, DNA-templated Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Histone Methylation Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone Modification Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Methylation Regulation Of Histone Modification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Regulation Of JNK Cascade
Tagcloud ?		3k36me3 abrogate astrocytomas base bs69 building childhood chondroblastoma composed consists copies disruption giant h2a h2b h3 h4 importantly missense nucleosome octamer pairs pediatric question raise reader somatic tumorigenesis wrapped	coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt drosophila earlier embryo embryogenesis enhancer esc evolution extra heed homologs hybrid impair maintain partnership pc polycomb repressors silencing zeste
Tagcloud (Difference) ?		3k36me3 abrogate astrocytomas base bs69 building childhood chondroblastoma composed consists copies disruption giant h2a h2b h3 h4 importantly missense nucleosome octamer pairs pediatric question raise reader somatic tumorigenesis wrapped	coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt drosophila earlier embryo embryogenesis enhancer esc evolution extra heed homologs hybrid impair maintain partnership pc polycomb repressors silencing zeste
Tagcloud (Intersection) ?