JTB and LIG3

Number of citations of the paper that reports this interaction (PMID 12897160)
44

Data Source:
HPRD (in vivo)

		JTB	LIG3
Gene Name		jumping translocation breakpoint	ligase III, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Spindle Integral Component Of Plasma Membrane Membrane Midbody	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Protein Kinase Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Cytokinesis Mitotic Nuclear Division Apoptotic Mitochondrial Changes Regulation Of Cell Proliferation Positive Regulation Of Protein Kinase Activity	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Mitochondrion Organization Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Recombination Cell Division DNA Biosynthetic Process
Pathways			Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Bleomycin
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		4 interactors: APP LIG3 TCEB1 ZXDC	9 interactors: APP JTB NEIL1 PARP1 PNKP TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		10899	3980
HPRD ID		05240	02966
Ensembl ID		ENSG00000143543	ENSG00000005156
Uniprot IDs		O76095	E5KLB5 E5KLB6 P49916
PDB IDs		2KJX	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction RNA Metabolic Process Collateral Sprouting In Absence Of Injury Base-excision Repair, DNA Ligation Otolith Morphogenesis Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Otolith Development Axon Choice Point Recognition Positive Regulation Of Cellular Biosynthetic Process Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair Nucleobase-containing Compound Metabolic Process Neuron Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Ligation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Copper Ion Homeostasis Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Metabolic Process DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity DNA Strand Elongation Mating Behavior Regulation Of Transcription Elongation From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Viral Transcription	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Hyperosmotic Salinity Response Cellular Response To Stress Double-strand Break Repair Cellular Response To X-ray Base-excision Repair Response To Stress Telomere Maintenance Establishment Of Integrated Proviral Latency DNA Damage Response, Detection Of DNA Damage Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Cellular Response To Salt Stress Single Strand Break Repair Response To Oxidative Stress Nucleobase-containing Compound Metabolic Process Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Cellular Nitrogen Compound Metabolic Process Hyperosmotic Response Cellular Response To Osmotic Stress Response To X-ray Nitrogen Compound Metabolic Process Response To Salt Stress Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Response To Ionizing Radiation Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Type I Interferon Production Response To Abiotic Stimulus Response To Osmotic Stress Negative Regulation Of Cellular Metabolic Process Nucleotide-excision Repair Regulation Of Type I Interferon Production Synaptic Growth At Neuromuscular Junction Negative Regulation Of Nuclease Activity Polynucleotide 3' Dephosphorylation Homeostatic Process Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation DNA Catabolic Process Cellular Response To Radiation Response To Stimulus
Tagcloud ?		advantages assessing breakpoint comprehensive conferred consequences define hairpin hbs hbsag hbv hcc hepatocellular hepg2 jumping mitochondria motility p65 promoted regards silenced silencing stably stronger suppress transfection translocation translocations unbalanced	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		advantages assessing breakpoint comprehensive conferred consequences define hairpin hbs hbsag hbv hcc hepatocellular hepg2 jumping mitochondria motility p65 promoted regards silenced silencing stably stronger suppress transfection translocation translocations unbalanced	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?