CGB and LHCGR

Number of citations of the paper that reports this interaction (PMID 2254302)
13

Data Source:
HPRD (in vivo)

		CGB	LHCGR
Gene Name		chorionic gonadotropin, beta polypeptide	luteinizing hormone/choriogonadotropin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity	Luteinizing Hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Apoptotic Process Signal Transduction Cell-cell Signaling Female Gamete Generation Peptide Hormone Processing Cellular Protein Metabolic Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Male Gonad Development Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Cognition Cellular Response To Gonadotropin Stimulus
Pathways		Peptide hormone metabolism Glycoprotein hormones Peptide hormone biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin
Diseases
GWAS			Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		4 interactors: APP CGA FSHB LHCGR	11 interactors: ARRB2 CANX CGA CGB CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR
Entrez ID		1082	3973
HPRD ID		00343	01073
Ensembl ID		ENSG00000104827	ENSG00000138039
Uniprot IDs		P01233	P22888
PDB IDs		1HCN 1HRP 1QFW 1XUL	1LUT 1XUL
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Peptide Metabolic Process Male Gonad Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Hormone Metabolic Process Male Sex Differentiation Positive Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Luteinizing Hormone Signaling Pathway Gonad Development Development Of Primary Sexual Characteristics Protein Processing Steroid Metabolic Process Reproductive Process Cellular Amide Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Hormone Levels Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Cognition Sex Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axon Choice Point Recognition Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Sertoli Cell Proliferation Neuron Remodeling Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of CAMP-mediated Signaling Signal Transduction Progesterone Biosynthetic Process Reproductive Structure Development Reproductive System Development Positive Regulation Of Bone Resorption Cellular Copper Ion Homeostasis Signaling Cell Communication Regulation Of Cell Migration	Cell-cell Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Processing Hormone Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Metabolic Process Signal Transduction Platelet Activation Dopamine Receptor Signaling Pathway Secretion Positive Regulation Of Signal Transduction Protein Processing Cell Activation Cellular Amide Metabolic Process Hormone Biosynthetic Process Cellular Response To Stimulus Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Transmission Acid Secretion Positive Regulation Of Intracellular Signal Transduction Regulation Of Cyclase Activity Renal Phosphate Ion Absorption Post-embryonic Body Morphogenesis Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Renal System Process Negative Regulation Of Sodium:proton Antiporter Activity Thyroid-stimulating Hormone Signaling Pathway Glutathione Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Protein Localization Adult Locomotory Behavior Cell Surface Receptor Signaling Pathway Secretion By Cell Protein Secretion Regulation Of Protein Kinase B Signaling Response To Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Reproductive Process
Tagcloud ?		apoc2 atp1a3 bckdha cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?