CGA and LHCGR

Number of citations of the paper that reports this interaction (PubMedID 10342833)
0

Data Source:
HPRD (in vitro)

		CGA	LHCGR
Description		glycoprotein hormones, alpha polypeptide	luteinizing hormone/choriogonadotropin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Follicle-stimulating Hormone Complex Pituitary Gonadotropin Complex	Endosome Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Hormone Activity Protein Binding Follicle-stimulating Hormone Activity	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Thyroid Hormone Generation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Gonad Development Hormone-mediated Signaling Pathway Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cell Migration Thyroid Gland Development Luteinizing Hormone Secretion Cellular Response To Hormone Stimulus Organ Growth Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Follicle-stimulating Hormone Secretion Developmental Growth	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Thyroxine biosynthesis Hormone ligand-binding receptors G alpha (s) signalling events TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Reactions specific to the complex N-glycan synthesis pathway	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases			Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Atrial fibrillation ( 29892015 30061737) Thyroid stimulating hormone levels ( 32769997)	A body shape index ( 34021172) Body mass index ( 28892062) Hip circumference adjusted for BMI ( 34021172) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128 22885925) Sex hormone-binding globulin levels ( 22829776) Triglyceride levels ( 32154731) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: CGB3 CGB5 FSHB FSHR LHB LHCGR PTN PTPN12 TSHB	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR
Entrez ID		1081	3973
HPRD ID		00342	01073
Ensembl ID		ENSG00000135346	ENSG00000138039
Uniprot IDs		A0A087WYZ4 P01215 Q6I9S8	P22888
PDB IDs		1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XWD 4AY9 4MQW 7FIG 7FIH 7FII 7T9I 7UTZ 7XW5 8I2G	7FIG 7FIH 7FII 7FIJ
Enriched GO Terms of Interacting Partners?		Female Gamete Generation Hormone Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Ovulation Cycle Process Ovarian Follicle Development Progesterone Biosynthetic Process Gamete Generation Sertoli Cell Proliferation Rhythmic Process Protein-hormone Receptor Activity C21-steroid Hormone Biosynthetic Process Reproductive Process Progesterone Metabolic Process Male Gonad Development Signaling Receptor Binding Developmental Process Involved In Reproduction Gonad Development Cellular Response To Gonadotropin Stimulus Uterus Development C21-steroid Hormone Metabolic Process Female Gonad Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Steroid Hormone Biosynthetic Process Response To Gonadotropin Regulation Of Hormone Levels Reproductive Structure Development Ketone Biosynthetic Process Regulation Of Hormone Metabolic Process Hormone Biosynthetic Process Regulation Of Bone Resorption G Protein-coupled Peptide Receptor Activity Regulation Of Bone Remodeling Tissue Regeneration Extracellular Space Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Regulation Of Osteoclast Differentiation Regulation Of Tissue Remodeling Regulation Of Steroid Biosynthetic Process Developmental Growth Steroid Biosynthetic Process Ketone Metabolic Process Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex	Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
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