PPIC and CAPNS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIC	CAPNS2
Description		peptidylprolyl isomerase C	calpain small subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Calpain Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Folding
Pathways			Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Proline
Diseases
GWAS		Aortic root size ( 19584346) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)	Thyroid hormone levels ( 23408906)
Interacting Genes		13 interacting genes: ARSA BANP CAPNS2 FAM25A FAM25C FAM25G LGALS3BP SGTA SGTB UBAP1 UBQLN1 UBQLN2 UBQLN4	9 interacting genes: APP ARMC10 CAPN2 CMTM5 OXNAD1 PHACTR3 PPIC PRPF31 RIN1
Entrez ID		5480	84290
HPRD ID		00459	16682
Ensembl ID		ENSG00000168938	ENSG00000256812
Uniprot IDs		P45877	Q96L46
PDB IDs		2ESL
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Cerebroside-sulfatase Activity Regulation Of Cellular Response To Stress Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Targeting To Membrane Identical Protein Binding Autophagy Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Autophagosome Assembly BAT3 Complex Binding Autophagosome Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Autophagy Calpain Complex Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Vesicle Cytosolic Proteasome Complex Regulation Of Protein Metabolic Process Negative Regulation Of ERAD Pathway	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization SnoRNA Localization U4atac SnRNA Binding Regulation Of Growth Rate DNA Binding Domain Binding Positive Regulation Of Growth Rate Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Spliceosomal Tri-snRNP Complex Import Into Cell Axon Choice Point Recognition U4 SnRNA Binding
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