LAMC1 and EIF3I

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		LAMC1	EIF3I
Gene Name		laminin, gamma 1 (formerly LAMB2)	eukaryotic translation initiation factor 3, subunit I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Extracellular Matrix Structural Constituent Glycosphingolipid Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Axon Guidance Endoderm Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Epithelial Cell Proliferation	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions Degradation of the extracellular matrix	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Colorectal cancer ( 23266556)
Protein-Protein Interactions		13 interactors: ANTXR2 APP ATF7IP CCDC53 CENPU EIF3I LAMA5 NID1 NID2 SNAPIN SNX2 SRPK1 TANK	34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM
Entrez ID		3915	8668
HPRD ID		01030	04884
Ensembl ID		ENSG00000135862	ENSG00000084623
Uniprot IDs		P11047 Q6NVY8	Q13347 Q5U0F4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Organization Cell-matrix Adhesion Viral Process Cell-substrate Adhesion Axon Cargo Transport Positive Regulation Of Late Endosome To Lysosome Transport Synaptic Growth At Neuromuscular Junction Extracellular Matrix Disassembly Collateral Sprouting In Absence Of Injury Terminal Button Organization Autophagic Vacuole Maturation Cell Recognition Cellular Component Assembly Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Lamellipodium Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Cell Projection Organization Nephron Development Regulation Of Protein Binding Cell Adhesion Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Synapse Organization Organelle Organization Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly DNA Packaging Endocytosis Negative Regulation Of Neuron Differentiation	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		5p adam10 brand clustered documented emerged erbb4 existed hdac7 helps igf1r intriguingly invasion meanwhile micrornas migration mir mirna mirnas overexpressed pax6 psen1 repressed simultaneously targets though tongue tscc utr	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Difference) ?		5p adam10 brand clustered documented emerged erbb4 existed hdac7 helps igf1r intriguingly invasion meanwhile micrornas migration mir mirna mirnas overexpressed pax6 psen1 repressed simultaneously targets though tongue tscc utr	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Intersection) ?