ACAT2 and ZNF76

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACAT2	ZNF76
Description		acetyl-CoA acetyltransferase 2	zinc finger protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Cholesterol biosynthesis
Drugs		S-Hydroxycysteine Coenzyme A
Diseases
GWAS		Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 30108283)	Height ( 18391951 25282103 31562340) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: AKT1 CDX2 CSNK2A1 LNX1 TERF1 WWOX ZNF76	93 interacting genes: ACAT2 ALOXE3 ANKRD37 ANTKMT ATP5PO BLZF1 BOLA2 BOLA2B C10orf55 C22orf15 C3orf36 CCDC33 CEACAM6 CEP76 CSN3 DDIT4L DISC1 ENKD1 EP300 EXOSC1 FAM228A FAM90A1 FCRL4 FNDC8 FSD2 GIMAP6 GRAPL HDAC1 HOMEZ HUNK IKZF3 KCTD9 KLF15 KPNA3 KRT40 KRT75 L3MBTL3 LAP3 LETM1 LHX3 LHX4 LHX6 LIN37 LIN54 LMO1 MAGEA6 MBD3L1 MBD5 MED19 MFAP1 MORN3 MRPL12 MTFR1L MTUS2 MYL10 NEDD9 NRIP2 PIAS1 PMPCA POGZ PRKAR1B RAB3IP RALY REL RNF214 RPRD1A RPS21 SCNM1 SLAIN1 SMAD1 SNAI2 SPANXN3 SPATA8 SPMIP10 STMN3 TASOR2 TBC1D22B TBP TEKT5 TGS1 TNNI1 USP54 USP6 USP7 VXN WDR83 YPEL3 ZC2HC1C ZC4H2 ZMYM6 ZNF420 ZNF526 ZNF623
Entrez ID		39	7629
HPRD ID		00006	01929
Ensembl ID		ENSG00000120437	ENSG00000065029
Uniprot IDs		Q9BWD1	P36508
PDB IDs		1WL4 1WL5
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Execution Phase Of Apoptosis Negative Regulation Of Translational Initiation Spindle Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of TRNA Methylation Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Differentiation Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Nervous System Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Proteolysis TRNA (guanine-N7)-methylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Regulation Of Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of DNA Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Rapamycin Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric-oxide Synthase Regulator Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation	Protein Binding Medial Motor Column Neuron Differentiation
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