ACAT2

Name	acetyl-CoA acetyltransferase 2
Structure
Novel Interactors	1 novel interactors: DYNLT1
Interactors	7 interactors: AKT1 CDX2 CSNK2A1 LNX1 TERF1 WWOX ZNF76
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process
Pathways	Cholesterol biosynthesis
Drugs	S-Hydroxycysteine Coenzyme A
GWAS	Erosive tooth wear (severe vs non-severe) ( 29898447 ) Lipoprotein (a) levels ( 30108283 )
Entrez ID	39
HPRD ID	00006
Ensembl ID	ENSG00000120437
Uniprot IDs	Q9BWD1
PDB IDs	1WL4 1WL5
GO Terms Enriched among Interactors ?	Identical Protein Binding Execution Phase Of Apoptosis Negative Regulation Of Translational Initiation Spindle Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of TRNA Methylation Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Differentiation Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Nervous System Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Proteolysis TRNA (guanine-N7)-methylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Regulation Of Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of DNA Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Rapamycin Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric-oxide Synthase Regulator Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation