KRT85 and KRT25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT85	KRT25
Description		keratin 85	keratin 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Keratin Filament	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Epidermis Development Keratinization Intermediate Filament Organization	Morphogenesis Of An Epithelium Cytoskeleton Organization Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cycle Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Ectodermal dysplasia, pure hair-nail type (HNED)
GWAS		Body mass index ( 28552196)	Asthma ( 30929738 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		27 interacting genes: ALOX12 CLIC3 CREB5 CYSRT1 GNE HAPLN2 KLHL38 KRT13 KRT14 KRT15 KRT16 KRT19 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT39 KRT40 LHX8 OTX1 TAB2 ZNF655	26 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 MORN4 PPL
Entrez ID		3891	147183
HPRD ID		04139	17242
Ensembl ID		ENSG00000135443	ENSG00000204897
Uniprot IDs		B7Z7N3 F5GYI5 P78386	Q6ZPD6 Q7Z3Z0
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Extracellular Exosome Epidermis Development Cell Differentiation Hair Cycle Cellular Developmental Process Developmental Process Organelle Organization Structural Constituent Of Cytoskeleton Establishment Of Skin Barrier Skin Epidermis Development Cytosol Tissue Development Cornified Envelope Hair Follicle Morphogenesis Hepoxilin-epoxide Hydrolase Activity Lipoxin B4 Biosynthetic Process Protein Binding Diencephalon Morphogenesis N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Leukotriene A4 Metabolic Process Lipoxin B4 Metabolic Process Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Intermediate Filament Cytoskeleton Protein-disulfide Reductase (glutathione) Activity N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Arachidonate 12(S)-lipoxygenase Activity Keratinocyte Differentiation Terminal Web Metencephalon Development Establishment Of Blood-nerve Barrier	Keratinization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Cytosol Cornified Envelope Epidermis Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Tissue Development Peptide Cross-linking Desmosome Intermediate Filament Polymerization Protein Binding Structural Molecule Activity Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Negative Regulation Of Entry Of Bacterium Into Host Cell Response To Wounding
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