KRT85 and ALOX12

Number of citations of the paper that reports this interaction (PMID 10727209)
7

Data Source:
HPRD (two hybrid)

		KRT85	ALOX12
Gene Name		keratin 85, type II	arachidonate 12-lipoxygenase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Keratin Filament	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Hepoxilin A3 Synthase Activity
	Biological Process	Epidermis Development	Movement Of Cell Or Subcellular Component Aging Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Superoxide Anion Generation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Reactive Oxygen Species Metabolic Process Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways			Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ALOX12	7 interactors: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3891	239
HPRD ID		04139	01066
Ensembl ID		ENSG00000135443	ENSG00000108839
Uniprot IDs		F5GYI5 P78386	P18054
PDB IDs			2ABU 3D3L
Enriched GO Terms of Interacting Partners?		Leukotriene A4 Metabolic Process Lipoxin B4 Biosynthetic Process Lipoxin A4 Biosynthetic Process Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Lipoxin Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Platelet Aggregation Linoleic Acid Metabolic Process Lipoxygenase Pathway Regulation Of Platelet Aggregation Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Endothelial Cell Differentiation Establishment Of Skin Barrier Superoxide Anion Generation Negative Regulation Of Platelet Activation Regulation Of Mitochondrial Depolarization Regulation Of Water Loss Via Skin Regulation Of Endothelial Cell Differentiation Regulation Of Platelet Activation Positive Regulation Of Vasodilation Leukotriene Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Membrane Depolarization Superoxide Metabolic Process Regulation Of Vasodilation Icosanoid Biosynthetic Process Multicellular Organismal Water Homeostasis Unsaturated Fatty Acid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Coagulation Water Homeostasis Arachidonic Acid Metabolic Process Negative Regulation Of Wound Healing Fatty Acid Oxidation Lipid Oxidation Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Migration Icosanoid Metabolic Process Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Proliferation Unsaturated Fatty Acid Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Homotypic Cell-cell Adhesion Reactive Oxygen Species Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Growth	Hemidesmosome Assembly Cell-substrate Junction Assembly Sterol Regulatory Element Binding Protein Import Into Nucleus
Tagcloud ?			agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Difference) ?			agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Intersection) ?