KRT33B and SHC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT33B	SHC3
Description		keratin 33B	SHC adaptor protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Cytosol Plasma Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Phosphotyrosine Residue Binding Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Cycle Intermediate Filament Organization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction
Pathways		Keratinization Formation of the cornified envelope	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		61 interacting genes: ABI2 AIMP2 AQP1 ARFIP1 ATG9A C1orf216 CCDC24 CNNM3 COX5B CYSRT1 DES DTNB DUSP21 FASLG FRS3 GOLGA6L2 GSTP1 HAPLN2 HDAC4 HGS HOXA1 INCA1 KDM1A KLC4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LMO4 MOS NUP54 NUP58 PATZ1 PPP1R18 RAB26 RAMAC RTP5 RUNX1T1 SCNM1 SGF29 SHC3 USP2 VPS37C	58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12
Entrez ID		3884	53358
HPRD ID		04136	12005
Ensembl ID		ENSG00000131738	ENSG00000148082
Uniprot IDs		Q14525	Q92529
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Epidermis Development Intermediate Filament Cytoskeleton Extracellular Exosome Cornified Envelope Tissue Development Developmental Process Structural Constituent Of Cytoskeleton	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Structural Constituent Of Skin Epidermis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Tissue Morphogenesis Regulation Of Apoptotic Process Morphogenesis Of An Epithelium Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade ERBB Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Kinase Activity ERBB2 Signaling Pathway Intermediate Filament Cellular Developmental Process Basal Plasma Membrane Positive Regulation Of Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Response To Growth Factor ERBB3:ERBB2 Complex Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Protein Phosphatase Binding Growth Factor Binding Myelination Anatomical Structure Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Axon Ensheathment Neuron Differentiation System Development
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