GLTPD2 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GLTPD2	PRDX4
Description		glycolipid transfer protein domain containing 2	peroxiredoxin 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Negative Regulation Of Interleukin-1 Beta Production Ceramide Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 22916037) Sphingomyelin levels ( 31551469)
Interacting Genes		1 interacting genes: PRDX4	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		388323	10549
HPRD ID		18609	05935
Ensembl ID		ENSG00000182327	ENSG00000123131
Uniprot IDs		A6NH11	Q13162 V9HW63
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Molecular Sequestering Activity Hydrogen Peroxide Catabolic Process Antioxidant Activity Peroxidase Activity Hydrogen Peroxide Metabolic Process Cell Redox Homeostasis Negative Regulation Of Reproductive Process Cellular Oxidant Detoxification Male Gonad Development Cellular Detoxification Reactive Oxygen Species Metabolic Process Ficolin-1-rich Granule Lumen Secretory Granule Lumen Gonad Development Regulation Of Reproductive Process Molecular Adaptor Activity Reproductive Structure Development Extracellular Matrix Organization Extracellular Structure Organization Protein Maturation	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin
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