CLEC12B and SCD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC12B	SCD
Description		C-type lectin domain family 12 member B	stearoyl-CoA desaturase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Regulator Activity Signaling Receptor Inhibitor Activity	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Palmitoyl-CoA 9-desaturase Activity Metal Ion Binding
	Biological Process	Natural Killer Cell Inhibitory Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Melanocyte Proliferation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Signaling Receptor Activity	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Monounsaturated Fatty Acid Biosynthetic Process
Pathways			Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Malaria ( 31844061) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Systolic blood pressure in sickle cell anemia ( 24058526)	Macular thickness ( 30535121) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: IL1RL1 JAGN1 LPAR3 LSMEM2 MALL OPRM1 PLLP PMP22 SCD SEC22A VMA21	44 interacting genes: APP AQP6 CD207 CD33 CERS4 CLEC12B CREB3L1 CYB561 CYB5A CYBC1 ERGIC3 FAM209A GJB1 GPR152 GPR42 GPX8 HSD17B13 JAGN1 KCNJ6 MARCHF5 MCFD2 MGST3 MTIF3 NEDD4L PVR REEP2 RETREG3 RNF5 SCN3B SEC11C SLC10A6 SLC18A1 SLC35H1 SLC71A2 SLC7A14 SPAG4 STOM TIMMDC1 TLCD4 TMEM30B TMPRSS2 TMX2 UBC VMA21
Entrez ID		387837	6319
HPRD ID		18266	04941
Ensembl ID		ENSG00000256660	ENSG00000099194
Uniprot IDs		A0A140VK10 Q2HXU8	O00767
PDB IDs			4ZYO
Enriched GO Terms of Interacting Partners?		Compact Myelin Myelination Axon Ensheathment Bleb Assembly Structural Constituent Of Myelin Sheath Membrane Myelin Assembly G-protein Alpha-subunit Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding Negative Regulation Of Protein Secretion Palmitoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity Regulation Of Transcytosis Endoplasmic Reticulum Cellular Response To Morphine Stearoyl-CoA 9-desaturase Activity Regulation Of NMDA Receptor Activity Lysophosphatidic Acid Receptor Activity Negative Regulation Of Protein Transport Endoplasmic Reticulum Membrane Granulocyte Colony-stimulating Factor Signaling Pathway Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Establishment Of Protein Localization Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Interleukin-1 Receptor Activity Myeloid Leukocyte Differentiation Negative Regulation Of Secretion By Cell	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport Sodium Channel Inhibitor Activity
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