KRT5 and KRT6A

Number of citations of the paper that reports this interaction (PubMedID 35575683)
0

Data Source:
BioGRID (cross-linking study)

		KRT5	KRT6A
Description		keratin 5	keratin 6A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate	Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Cutaneous squamous cell carcinoma ( 32041948)
Interacting Genes		30 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PKP2 RNF26 TCHP UBE3A	37 interacting genes: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
Entrez ID		3852	3853
HPRD ID		01010	01011
Ensembl ID		ENSG00000186081	ENSG00000205420
Uniprot IDs		P13647	A0A0S2Z428 P02538
PDB IDs		3TNU 6JFV	5KI0
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway
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