KLRG1 and GPR42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLRG1	GPR42
Description		killer cell lectin like receptor G1	G protein-coupled receptor 42
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Signaling Receptor Activity	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Innate Immune Response	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Refractive error ( 32231278) Sjögren's syndrome ( 28076899) Type 1 diabetes ( 34012112)
Interacting Genes		7 interacting genes: ARL13B GPR42 GPX8 KLRC1 LEPROTL1 MRM1 SYNE4	110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		10219	2866
HPRD ID		16076	16033
Ensembl ID		ENSG00000139187	ENSG00000126251
Uniprot IDs		Q96E93	A0A0K0PUY3 O15529
PDB IDs		3FF7
Enriched GO Terms of Interacting Partners?		Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Telencephalon Cell Migration Establishment Or Maintenance Of Apical/basal Cell Polarity Forebrain Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Inhibitory MHC Class Ib Receptor Activity Aortic Valve Formation Establishment Of Cell Polarity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration HLA-E Specific Inhibitory MHC Class Ib Receptor Activity RRNA (guanosine-2'-O-)-methyltransferase Activity Beta Selection Epithelial Tube Morphogenesis Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation Receptor Localization To Non-motile Cilium Bone Trabecula Morphogenesis Formation Of Radial Glial Scaffolds Apolipoprotein A-I-mediated Signaling Pathway Establishment Or Maintenance Of Cell Polarity Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation MHC Class Ib Receptor Activity Positive Regulation Of Lipase Activity Cleavage Furrow Formation Cell Morphogenesis Apical Junction Assembly Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton MHC Class I Protein Complex Binding Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Negative Regulation Of Cell Size Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Protein Antigen Binding	Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion
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