KIR2DL3 and CISD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIR2DL3	CISD2
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	CDGSH iron sulfur domain 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Immune Response-regulating Signaling Pathway Immune Response	Autophagy Of Mitochondrion Autophagy Regulation Of Autophagy
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS			Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		64 interacting genes: ADGRE2 AGTRAP AIG1 ANKRD46 APOA2 APOD APP AQP10 ASGR1 ATP6V0E1 BMP10 BRICD5 BTN2A2 C3orf52 CDIPT CISD2 CLDN19 CLN6 COQ9 CXCL16 CXCL9 CYB5B CYBC1 EMD FAM209A FAM3C FUNDC2 GAST GJA8 GPR108 GPX8 HLA-C IFITM3 INSIG2 ITGAM JAGN1 KTN1 LAT LCK LEUTX LHFPL5 NINJ2 NRM NSG1 OLFM4 PLN PLPPR2 PTPN6 RNF152 RTP2 SEC22B SLC38A7 SMIM1 SNORC THBD TMEM218 TMEM222 TMEM243 TMEM86B TMEM97 TRAF3IP3 UPK1B UPK2 VAMP5	58 interacting genes: AIG1 APOL2 APP AQP10 ARLN BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		3804	493856
HPRD ID		10383	17413
Ensembl ID		ENSG00000243772	ENSG00000145354
Uniprot IDs		E3NZD8 P43628	Q8N5K1
PDB IDs		1B6U 6PAG 8TUI	3FNV 4OO7 4OOA 7P0P
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cholesterol Binding CD27 Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Lipid Metabolic Process
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