KIR2DL3 and TRAF3IP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIR2DL3	TRAF3IP3
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	TRAF3 interacting protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity
	Biological Process	Immune Response-regulating Signaling Pathway Immune Response	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Orofacial clefts ( 33137956) Red blood cell count ( 27863252 32888494) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		64 interacting genes: ADGRE2 AGTRAP AIG1 ANKRD46 APOA2 APOD APP AQP10 ASGR1 ATP6V0E1 BMP10 BRICD5 BTN2A2 C3orf52 CDIPT CISD2 CLDN19 CLN6 COQ9 CXCL16 CXCL9 CYB5B CYBC1 EMD FAM209A FAM3C FUNDC2 GAST GJA8 GPR108 GPX8 HLA-C IFITM3 INSIG2 ITGAM JAGN1 KTN1 LAT LCK LEUTX LHFPL5 NINJ2 NRM NSG1 OLFM4 PLN PLPPR2 PTPN6 RNF152 RTP2 SEC22B SLC38A7 SMIM1 SNORC THBD TMEM218 TMEM222 TMEM243 TMEM86B TMEM97 TRAF3IP3 UPK1B UPK2 VAMP5	47 interacting genes: ATG16L1 CBARP CCDC136 CCDC138 CCDC88B CCNC CDCA7L CEP68 CEP70 COQ9 CPLX4 CREB3L3 EBAG9 EMD EVI2B FAM209A FATE1 GOLGA6L9 GOLM2 GORAB GRAMD2A KASH5 KIR2DL3 KRT27 L3MBTL3 LIME1 LRRC25 MFF MINAR1 NDEL1 OSBPL3 PLEKHO1 PSTPIP1 RACGAP1 RIC3 RILPL1 SP100 STMN4 STX1A STX4 TFIP11 TMEM139 TRAF3 TRIM36 WAC ZNRD2 ZRANB1
Entrez ID		3804	80342
HPRD ID		10383	16305
Ensembl ID		ENSG00000243772	ENSG00000009790
Uniprot IDs		E3NZD8 P43628	B1AJU2 B3KWQ9 E2QRE5 Q9Y228
PDB IDs		1B6U 6PAG 8TUI
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cholesterol Binding CD27 Signaling Pathway	Identical Protein Binding Organelle Organization
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