CENPS and CENPT

Number of citations: 65 (PubMedID 24522885)
Data Source: BioGRID (fluorescent resonance energy transfer)

		CENPS	CENPT
Name		centromere protein S	centromere protein T
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Chromosome Segregation Replication Fork Processing Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Cell Division	Mitotic Cell Cycle Chromosome Segregation Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Fanconi Anemia Pathway Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		No GWAS studies recorded	Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Interacting Genes		5 interacting genes: APP CENPM CENPT CENPX HOMEZ	8 interacting genes: APP CENPS COPS5 DHX29 H3C1 PPCDC SNCB TCEA2
Entrez ID		378708	80152
HPRD ID		18797	07811
Ensembl ID		ENSG00000175279	ENSG00000102901
Uniprot IDs		Q8N2Z9	B3KPB2 Q96BT3
PDB IDs		4DRA 4DRB 4E44 4E45 4NDY 4NE1 4NE3 4NE5 4NE6 7R5S 7XHN 7XHO 7YWX	7QOO 7R5S 7XHN 7XHO 7YWX
GO Terms Enriched among Interactors		Inner Kinetochore Chromosome Segregation Kinetochore Chromosome, Centromeric Region Kinetochore Organization Kinetochore Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromosome Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling FANCM-MHF Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Membraneless Organelle Assembly Cytosol Antifungal Humoral Response Nuclear Envelope Lumen Acetylcholine Receptor Binding	Transition Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Translation Initiation Factor Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Protein Heterodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Macrophage Migration Inhibitory Factor Binding Translational Initiation Nitric-oxide Synthase Complex