CENPT and CYB5B

		CENPT	CYB5B
Description		centromere protein T	cytochrome b5 type B
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Protein Binding Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Chromosome Organization Cell Division Kinetochore Assembly	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)
Interacting Genes		8 interacting genes: APP CENPS COPS5 DHX29 H3C1 PPCDC SNCB TCEA2	51 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP ERGIC3 FAM209A FAM210B FKBP7 FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A1 SLC10A6 SLC16A2 SLC35H1 SLC39A9 SLC60A2 SLC71A2 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		80152	80777
HPRD ID		07811	13106
Ensembl ID		ENSG00000102901	ENSG00000103018
Uniprot IDs		B3KPB2 Q96BT3	O43169
PDB IDs		7QOO 7R5S 7XHN 7XHO 7YWX	3NER
Enriched GO Terms of Interacting Partners?		Transition Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Translation Initiation Factor Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Protein Heterodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Macrophage Migration Inhibitory Factor Binding Translational Initiation Nitric-oxide Synthase Complex	Membrane
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