KCNN2 and ACTN2

Number of citations of the paper that reports this interaction (PubMedID 19815520)
32

Data Source:
BioGRID (pull down)

		KCNN2	ACTN2
Description		potassium calcium-activated channel subfamily N member 2	actinin alpha 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Z Disc Neuronal Cell Body Dendritic Spine	Extracellular Region Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynaptic Density Membrane Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Domain Specific Binding Protein Homodimerization Activity Alpha-actinin Binding	Transcription Coactivator Activity Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Titin Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport	Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity
Pathways		Ca2+ activated K+ channels Acetylcholine inhibits contraction of outer hair cells	Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine Rimtuzalcap
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Atrial fibrillation ( 28416818 29892015 30061737 33990960) Coronary arterial lesions in patients with Kawasaki disease ( 23677057) Diastolic blood pressure ( 27841878) Generalized epilepsy ( 30531953) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) JT interval (sulfonylurea treatment interaction) ( 27958378) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systolic blood pressure ( 27841878)	Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		4 interacting genes: ACTN2 CALM1 SRPK1 SRPK2	110 interacting genes: ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CIMAP1B CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID		3781	88
HPRD ID		09323	00019
Ensembl ID		ENSG00000080709	ENSG00000077522
Uniprot IDs		A0A3F2YNY5 Q9H2S1	P35609
PDB IDs		5V02 5WBX 5WC5 6ALE	1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3 7A8T 7A8U 7B55 7B56 7B57
Enriched GO Terms of Interacting Partners?		Titin Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Sarcomere Positive Regulation Of Viral Process Regulation Of Transmembrane Transporter Activity Actin Filament Uncapping Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Viral Genome Replication Negative Regulation Of Viral Process RNA Exonuclease Activity, Producing 5'-phosphomonoesters Negative Regulation Of Monoatomic Ion Transport Regulation Of Viral Life Cycle MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Transmembrane Transporter Binding Titin Z Domain Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of MRNA Processing Regulation Of Viral Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Regulation Of RNA Splicing Nuclear Speck Organization 5'-3' RNA Exonuclease Activity Cell Junction FATZ Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Magnesium Ion Binding Protein-RNA Complex Assembly Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking Positive Regulation Of Endocytic Recycling Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity R-loop Processing Regulation Of Monoatomic Ion Transmembrane Transport Postsynaptic Actin Cytoskeleton	Z Disc Muscle Alpha-actinin Binding Actin Binding Alpha-actinin Binding Postsynaptic Density Regulation Of Neuronal Synaptic Plasticity Sarcomere Organization Protein Binding Actin Cytoskeleton Actin Filament-based Process Telethonin Binding Organelle Organization Cytoplasm Neuron Projection Actin Cytoskeleton Organization Calmodulin Binding Actomyosin Structure Organization Cytoskeleton Organization Actinin Binding Calcium- And Calmodulin-dependent Protein Kinase Complex FATZ Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Cytoskeletal Protein Binding Regulation Of Synaptic Plasticity Regulation Of Transport Intracellular Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Structural Constituent Of Muscle Cell Adhesion Nuclear Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Metal Ion Transport Regulation Of Signal Transduction Stress Fiber Regulation Of Multicellular Organismal Process Adherens Junction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Kinase Binding Locomotor Rhythm Cell Projection Organization Protein-containing Complex Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Transport Calcium-mediated Signaling
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