USP17L2 and LGMN

Number of citations of the paper that reports this interaction (PubMedID 24610907)
0

Data Source:
BioGRID (enzymatic study, biochemical, affinity chromatography technology)

		USP17L2	LGMN
Description		ubiquitin specific peptidase 17 like family member 2	legumain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Tau Protein Binding Endopeptidase Activator Activity
	Biological Process	MAPK Cascade Proteolysis Apoptotic Process Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Maturation Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Ub-specific processing proteases RAS processing	Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Change in serum metabolite levels (CMS) ( 31636271) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		11 interacting genes: BRD4 CDK4 CDK6 ELK1 KLF4 KMT5A LGMN LINC02487 SIRT7 UBC ZBTB7A	6 interacting genes: AMPH LAMC3 MAPT SET SRPK2 USP17L2
Entrez ID		377630	5641
HPRD ID		16844	04017
Ensembl ID		ENSG00000223443	ENSG00000100600
Uniprot IDs		Q6R6M4	Q53XC6 Q96CY7 Q99538
PDB IDs			4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB 7FQH 7FQI 7FQJ 7FQK 7FQL 7O50 8AE4 8AE5
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Chromatin Remodeling Histone H4K8ac Reader Activity Nucleolus Organizer Region Polytene Chromosome Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Response To Growth Factor Negative Regulation Of Signal Transduction	Regulation Of Superoxide Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Intramembranous Bone Growth
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