TOPAZ1 and XCR1

Data Source: HiPPIP (Novel)

		TOPAZ1	XCR1
Name		testis and ovary specific TOPAZ 1	X-C motif chemokine receptor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	None	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Apoptotic Process Spermatogenesis Cell Differentiation Ectopic Germ Cell Programmed Cell Death Spermatocyte Division LncRNA Transcription	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Response To Cytokine Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		None	Chemokine receptors bind chemokines G alpha (q) signalling events
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Depression ( 29700475 ) General risk tolerance (MTAG) ( 30643258 )	Aspartate aminotransferase levels ( 33547301 ) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485 ) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485 )
Novel Interactors		5 novel interactors: QARS1 TCAIM TNNC1 WDR48 XCR1	2 novel interactors: PRKAR2A TOPAZ1
Interacting Genes		None recorded	3 interacting genes: PLEKHF2 XCL1 XCL2
Entrez ID		375337	2829
HPRD ID		19563	02774
Ensembl ID		ENSG00000173769	ENSG00000173578
Uniprot IDs		Q8N9V7	P46094 Q502V0 Q689E2
PDB IDs		Not available	9AST
GO Terms Enriched among Interactors		Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of Muscle Filament Sliding Speed Diaphragm Contraction Troponin I Binding Regulation Of Muscle Filament Sliding Troponin T Binding Cardiac Troponin Complex Involuntary Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Protein Monoubiquitination Deubiquitinase Activator Activity Negative Regulation Of Stress-activated MAPK Cascade Troponin Complex Cardiac Muscle Cell Contraction Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Skeletal Muscle Adaptation	CCR Chemokine Receptor Binding Positive Regulation Of Granzyme A Production Chemokine Activity Negative Regulation Of T-helper 1 Cell Activation Chemokine-mediated Signaling Pathway Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Spermatocyte Division G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Thymocyte Migration Antimicrobial Humoral Response LncRNA Transcription Positive Regulation Of Natural Killer Cell Chemotaxis Cell Chemotaxis Cytokine Activity CAMP-dependent Protein Kinase Regulator Activity Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Humoral Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Proliferation CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Nucleotide-activated Protein Kinase Complex Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Chemotaxis Protein Kinase A Catalytic Subunit Binding Positive Regulation Of T Cell Chemotaxis Locomotion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Ectopic Germ Cell Programmed Cell Death CAMP Binding Regulation Of CD4-positive, Alpha-beta T Cell Proliferation