DND1 and APOBEC1

Number of citations of the paper that reports this interaction (PubMedID 18509452)
58

Data Source:
BioGRID (pull down)

		DND1	APOBEC1
Description		DND microRNA-mediated repression inhibitor 1	apolipoprotein B mRNA editing enzyme catalytic subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	Germ Cell Development Spermatogenesis MRNA Stabilization Negative Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			mRNA Editing: C to U Conversion Formation of the Editosome
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: APOBEC1 RBPMS2	16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2
Entrez ID		373863	339
HPRD ID		13240	02531
Ensembl ID		ENSG00000256453	ENSG00000111701
Uniprot IDs		Q8IYX4	P41238
PDB IDs		6LE1 7Q4L	6X91
Enriched GO Terms of Interacting Partners?		MRNA Modification Lipoprotein Transport Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Cytidine To Uridine Editing MRNA Editing Complex Lipoprotein Biosynthetic Process Base Conversion Or Substitution Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine Deaminase Activity Negative Regulation Of Triglyceride Metabolic Process Low-density Lipoprotein Particle Clearance Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Apolipoprotein B MRNA Editing Enzyme Complex Embryonic Digestive Tract Morphogenesis Negative Regulation Of Smooth Muscle Cell Differentiation MRNA 3'-UTR AU-rich Region Binding Plasma Lipoprotein Particle Clearance Lipoprotein Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Gene Expression, Epigenetic Response To Gamma Radiation Transcription Initiation-coupled Chromatin Remodeling MRNA Stabilization Triglyceride Metabolic Process RNA Binding Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process Acylglycerol Metabolic Process RNA Stabilization Neutral Lipid Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of RNA Catabolic Process Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Lipid Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of BMP Signaling Pathway Embryonic Organ Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus	MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression
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