GCLM and OSGIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GCLM	OSGIN1
Description		glutamate-cysteine ligase modifier subunit	oxidative stress induced growth inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Midbody
	Molecular Function	Glutamate-cysteine Ligase Activity Protein Binding Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding Glutamate-cysteine Ligase Regulator Activity	Monooxygenase Activity Protein Binding Growth Factor Activity Oxidoreductase Activity
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Nutrient Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Response To Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth
Pathways		Glutathione synthesis and recycling Defective GCLC causes HAGGSD NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Glutamic acid Cysteine
Diseases
GWAS		Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: CALM1 CFTR IRF7 OSGIN1 STOX1	47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4
Entrez ID		2730	29948
HPRD ID		03106	06412
Ensembl ID		ENSG00000023909	ENSG00000140961
Uniprot IDs		P48507	Q9UJX0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transmembrane Transporter Activity Membrane Docking Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Otic Vesicle Morphogenesis Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MDA-5 Signaling Pathway Cellular Response To Nitrosative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transepithelial Water Transport Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Mitochondrial DNA Metabolic Process Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Autophagosome Membrane Docking Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Response To Nitrosative Stress Regulation Of Monoatomic Ion Transmembrane Transport Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Multicellular Organismal Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Binding DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process Nervous System Development Activation-induced Cell Death Of T Cells Identical Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Developmental Process Response To Nitrosative Stress Positive Regulation Of Proteolysis CAMP Catabolic Process Regulation Of Cell Communication Regulation Of Signaling System Development Regulation Of Cell Population Proliferation Anoikis HMG Box Domain Binding Nucleus Embryonic Pattern Specification Cyclic Nucleotide Catabolic Process Myelin Maintenance Nucleoplasm Positive Regulation Of Intracellular Signal Transduction Segment Specification
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