GCLM and IRF7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GCLM	IRF7
Gene Name		glutamate-cysteine ligase, modifier subunit	interferon regulatory factor 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	Glutamate-cysteine Ligase Activity Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity DNA Binding Protein Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Apoptotic Mitochondrial Changes Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Glutamate-cysteine Ligase Activity Response To Drug Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Regulation Of Blood Vessel Size Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Adaptive Immune Response Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Cytokine-mediated Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Type I Interferon Biosynthetic Process Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Toll Like Receptor 7/8 (TLR7/8) Cascade Interferon Signaling Cytokine Signaling in Immune system Factors involved in megakaryocyte development and platelet production MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Interferon alpha/beta signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs		L-Glutamic Acid L-Cysteine
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		4 interactors: CALM1 GCLC IRF7 STOX1	25 interactors: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		2730	3665
HPRD ID		03106	05441
Ensembl ID			ENSG00000185507
Uniprot IDs		M5A959 P48507	M9RSF4 Q92985
PDB IDs			2O61
Enriched GO Terms of Interacting Partners?		Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Ion Homeostasis MDA-5 Signaling Pathway Monosaccharide Metabolic Process Interferon-beta Production Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Response To Nitrosative Stress Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Negative Regulation Of Cellular Metabolic Process Mitochondrion Organization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Metabolic Process Establishment Of Viral Latency Immune Response-regulating Signaling Pathway Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Type I Interferon Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Detection Of Calcium Ion L-ascorbic Acid Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Regulation Of Monocyte Differentiation Type I Interferon Production Regulation Of Macrophage Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Virus Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Mitochondrial Depolarization Negative Regulation Of Peptidyl-threonine Phosphorylation Glutathione Biosynthetic Process Regulation Of Signaling Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Positive Regulation Of Interferon-alpha Production Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Immune Response Response To Biotic Stimulus Regulation Of Cytokine Production Viral Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Interferon-beta Production Cellular Response To Lipopolysaccharide Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Bacterium Defense Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Regulation Of Interferon-beta Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Chemokine Production
Tagcloud ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclc hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz	abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer
Tagcloud (Difference) ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclc hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz	abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer
Tagcloud (Intersection) ?