IL1R2 and IL1RN

Number of citations of the paper that reports this interaction (PubMedID 1834644)
0

Data Source:
HPRD (in vivo)

		IL1R2	IL1RN
Description		interleukin 1 receptor type 2	interleukin 1 receptor antagonist
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Extracellular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Processing Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Acute-phase Response Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling	Interleukin-10 signaling Interleukin-1 signaling
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Ankylosing spondylitis ( 20062062 23749187) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 23128233 28067908) Parkinson's disease ( 28892059 32201043) Ulcerative colitis ( 21297633)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 29878111) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spondylosis ( 33332786) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15	6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		7850	3557
HPRD ID		00995	00978
Ensembl ID		ENSG00000115590	ENSG00000136689
Uniprot IDs		P27930	P18510
PDB IDs		3O4O	1ILR 1ILT 1IRA 1IRP 2IRT
Enriched GO Terms of Interacting Partners?		Interleukin-1 Receptor Binding Acute-phase Response Fever Generation Acute Inflammatory Response Positive Regulation Of Immature T Cell Proliferation In Thymus Heat Generation Positive Regulation Of Interleukin-6 Production Regulation Of Immature T Cell Proliferation In Thymus Inflammatory Response Regulation Of Interleukin-6 Production Ectopic Germ Cell Programmed Cell Death Programmed Cell Death Involved In Cell Development Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Temperature Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interleukin-2 Production Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Mitotic Nuclear Division Immune Response Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Interleukin-2 Production Defense Response Negative Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Division Negative Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Molecule Production Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Proliferation Extrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Nuclear Division Negative Regulation Of Gap Junction Assembly Interleukin-33 Receptor Activity Interleukin-1, Type II Receptor Binding Interleukin-1, Type I Receptor Binding Negative Regulation Of Antifungal Innate Immune Response Immune System Process Regulation Of Nuclear Division Positive Regulation Of Lymphocyte Proliferation	Interleukin-1 Binding Interleukin-1 Receptor Activity Shelterin Complex Regulation Of Interleukin-1-mediated Signaling Pathway Protein Deneddylation Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Regulation Of Protein Neddylation Protein Neddylation Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening COP9 Signalosome Negative Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Interleukin-1, Type I, Activating Receptor Activity Negative Regulation Of Interleukin-1 Alpha Production Regulation Of Cellular Response To Stress Protein Modification By Small Protein Removal Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Neutrophil Extravasation Regulation Of Metabolic Process Single-stranded Telomeric DNA Binding Regulation Of Neutrophil Extravasation DeNEDDylase Activity
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