IL1RN

Description		interleukin 1 receptor antagonist
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Acute-phase Response Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling
Drugs		Rilonacept
Diseases		Graft-versus-host disease
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 29878111) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Spondylosis ( 33332786) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		3557
HPRD ID		00978
Ensembl ID		ENSG00000136689
Uniprot IDs		P18510
PDB IDs		1ILR 1ILT 1IRA 1IRP 2IRT
Enriched GO Terms of Interacting Partners?		Interleukin-1 Binding Interleukin-1 Receptor Activity Shelterin Complex Regulation Of Interleukin-1-mediated Signaling Pathway Protein Deneddylation Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Regulation Of Protein Neddylation Protein Neddylation Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening COP9 Signalosome Negative Regulation Of Telomere Maintenance Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Interleukin-1, Type I, Activating Receptor Activity Negative Regulation Of Interleukin-1 Alpha Production Regulation Of Cellular Response To Stress Protein Modification By Small Protein Removal Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Neutrophil Extravasation Regulation Of Metabolic Process Single-stranded Telomeric DNA Binding Regulation Of Neutrophil Extravasation DeNEDDylase Activity
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