VWA2 and PTPN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VWA2	PTPN3
Description		von Willebrand factor A domain containing 2	protein tyrosine phosphatase non-receptor type 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Calcium-independent Cell-matrix Adhesion Regulation Of Insulin Receptor Signaling Pathway	MAPK Cascade Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways			EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte count ( 32888494) Monocyte count ( 32888494)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin levels ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: PTPN3 TRAF2	25 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB ZAP70 ZCCHC10
Entrez ID		340706	5774
HPRD ID		16481	06767
Ensembl ID		ENSG00000165816	ENSG00000070159
Uniprot IDs		Q5GFL6	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs			2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36 8CQY 8OEP
Enriched GO Terms of Interacting Partners?		Cytoplasmic Side Of Plasma Membrane TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Catabolic Process Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential CD27 Signaling Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Thioesterase Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Intracellular Signaling Cassette Programmed Necrotic Cell Death Response To Nitric Oxide Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Sodium Channel Regulator Activity Positive Regulation Of T Cell Cytokine Production Positive Regulation Of MAP Kinase Activity Signal Transduction Involved In Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-2 Production Vesicle Membrane Regulation Of T Cell Cytokine Production Phosphotyrosine Residue Binding Regulation Of Membrane Depolarization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity	Positive Regulation Of Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Temperature Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Growth Cellular Response To Vascular Endothelial Growth Factor Stimulus TRNA Methylation Maternal Process Involved In Female Pregnancy Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Autophagy Response To Heat Positive Regulation Of Endothelial Cell Migration Response To Food Response To Growth Hormone Regulation Of TRNA Methylation Response To Lipid Negative Regulation Of Cell Communication Identical Protein Binding Positive Regulation Of Protein Localization To Cell Surface T Cell Receptor Complex Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Protein Phosphatase Binding Negative Regulation Of Protein Kinase C Signaling Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Flavin Adenine Dinucleotide Catabolic Process Enzyme Regulator Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Activation Regulation Of Endothelial Cell Migration Regulation Of Protein Localization To Cell Surface Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Positive Regulation Of Biosynthetic Process
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