RXFP4 and RLN3

Number of citations of the paper that reports this interaction (PMID 14522967)
21

Data Source:
HPRD (in vivo)

		RXFP4	RLN3
Gene Name		relaxin/insulin-like family peptide receptor 4	relaxin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Angiotensin Type II Receptor Activity Protein Binding	G-protein Coupled Receptor Binding Hormone Activity Protein Binding
	Biological Process	Angiotensin-activated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: KNG1 RLN3	3 interactors: RXFP1 RXFP3 RXFP4
Entrez ID		339403	117579
HPRD ID		16421	06031
Ensembl ID		ENSG00000173080
Uniprot IDs		Q8TDU9	Q8WXF3
PDB IDs			2FHW 2K1V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Platelet Activation Negative Regulation Of Cell Adhesion Muscle Contraction Muscle System Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Positive Regulation Of Secretion Exocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Hemostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Secretion By Cell Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death See more	G-protein Coupled Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Parturition Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		amidated amidation amide arousal behavioural bonds carboxyl chain chains chemically circular cognate connected dichroism disulfide drop feeding modification modulatory neuropeptide orientation primarily relaxin rxfp3 spectroscopy structurally synthesised termini terminus	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Difference) ?		amidated amidation amide arousal behavioural bonds carboxyl chain chains chemically circular cognate connected dichroism disulfide drop feeding modification modulatory neuropeptide orientation primarily relaxin rxfp3 spectroscopy structurally synthesised termini terminus	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Intersection) ?