RXFP4 and TTC4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		RXFP4	TTC4
Description		relaxin family peptide/INSL5 receptor 4	tetratricopeptide repeat domain 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Galanin Receptor Activity Protein Binding	Protein Binding Hsp70 Protein Binding Hsp90 Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Feeding Behavior	Immune System Process Protein Folding Innate Immune Response Defense Response To Virus
Pathways		G alpha (i) signalling events Relaxin receptors
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: ACTR10 GAPDH GJA8 KNG1 MAGED1 QDPR RLN3 TSPAN3 TTC4 TTI1	3 interacting genes: OGT RXFP4 SNAPC3
Entrez ID		339403	7268
HPRD ID		16421	08417
Ensembl ID		ENSG00000173080	ENSG00000243725
Uniprot IDs		Q8TDU9	O95801
PDB IDs		7YJ4 7YK6 7YK7	6HFO
Enriched GO Terms of Interacting Partners?			Bent DNA Binding SnRNA-activating Protein Complex RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Galanin Receptor Activity SnRNA Transcription By RNA Polymerase III Regulation Of Transcription By Glucose SnRNA Transcription By RNA Polymerase II NSL Complex Positive Regulation Of Feeding Behavior RNA Polymerase III General Transcription Initiation Factor Activity SnRNA Transcription Core Promoter Sequence-specific DNA Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Feeding Behavior
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