IRF8 and PPIG

		IRF8	PPIG
Description		interferon regulatory factor 8	peptidylprolyl isomerase G
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism	Protein Folding RNA Splicing
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses
Drugs			Proline
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 27863252 32888494 23314186 28193307 29403010) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 19525953 24076602 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe insulin-deficient type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	26 interacting genes: BEND7 CACNA1A CEP70 CLK1 DAB1 DACH1 FHL3 KCTD6 LGALS3 PCBP1 PNMA2 PNN POLR2A PPCDC PRPF38A PRPF40A RNF10 SLU7 SMN1 SMN2 SP1 TFCP2 THAP1 TRIM54 YWHAG ZCCHC10
Entrez ID		3394	9360
HPRD ID		03336	12083
Ensembl ID		ENSG00000140968	ENSG00000138398
Uniprot IDs		H3BRT4 Q02556	Q13427
PDB IDs			2GW2 2WFI 2WFJ 5YZG
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid	MRNA Metabolic Process RNA Splicing RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Processing DNA-templated Transcription Termination Z Disc Nucleus Nucleic Acid Metabolic Process SMN Complex Gemini Of Cajal Bodies Spliceosomal Complex Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Biosynthetic Process Cytoplasmic Ribonucleoprotein Granule SMN-Sm Protein Complex RNA Binding Nuclear Speck Transcription Cis-regulatory Region Binding DNA Binding Nucleoplasm Protein Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Second Spliceosomal Transesterification Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex
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