CENATAC and NAT10

Number of citations of the paper that reports this interaction (PubMedID 31722219)
0

Data Source:
BioGRID (pull down, enzymatic study)

		CENATAC	NAT10
Description		centrosomal AT-AC splicing factor	N-acetyltransferase 10
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane Midbody Small-subunit Processome
	Molecular Function	Protein Binding	TRNA Binding Nucleotide Binding RNA Binding Protein Binding ATP Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups TRNA Cytidine N4-acetyltransferase Activity DNA Polymerase Binding MRNA N-acetyltransferase Activity 18S RRNA Cytidine N-acetyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Centrosome Duplication Regulation Of Protein Catabolic Process Chromosome Separation	RRNA Modification TRNA Wobble Cytosine Modification RRNA Processing Regulation Of Translation Protein Acetylation TRNA Processing RNA Modification Regulation Of Centrosome Duplication RRNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Translation TRNA Acetylation RRNA Acetylation Involved In Maturation Of SSU-rRNA
Pathways			rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: MESD MRPL38 NAT10 NDOR1 PPIL3 SIRT1 ZNF114	11 interacting genes: CD2BP2 CENATAC MDM2 PARP1 SREK1 SUMO2 TP53 UBC UBE2D2 UBE2I USP7
Entrez ID		338657	55226
HPRD ID		13234	10964
Ensembl ID		ENSG00000186166	ENSG00000135372
Uniprot IDs		Q86UT8	Q9H0A0
PDB IDs		8Y6O	6VLA 7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		Regulation Of Centrosome Cycle NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Protein Acetylation Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Centrosome Duplication Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity NADPH-iron-sulfur [2Fe-2S] Protein Oxidoreductase Activity TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity NAD-dependent Protein Lysine Delactylase Activity Regulation Of Cellular Response To Testosterone Stimulus Behavioral Response To Starvation Negative Regulation Of Peptidyl-lysine Acetylation Histone H4K16 Deacetylase Activity, NAD-dependent Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Negative Regulation Of Prostaglandin Biosynthetic Process Protein Depropionylation Positive Regulation Of Macrophage Apoptotic Process ENoSc Complex Positive Regulation Of CAMP-dependent Protein Kinase Activity NADPH-hemoprotein Reductase Activity Negative Regulation Of Protein Acetylation Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Mobilization Pyrimidine Dimer Repair By Nucleotide-excision Repair HLH Domain Binding Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Histone Deacetylase Activity, NAD-dependent Regulation Of CAMP-dependent Protein Kinase Activity RDNA Heterochromatin Chromosome, Telomeric Region Keratin Filament Binding Protein Folding RDNA Heterochromatin Formation Regulation Of Endodeoxyribonuclease Activity Stress-induced Premature Senescence NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Ovulation From Ovarian Follicle	Post-translational Protein Modification SUMO Transferase Activity PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Cellular Response To Actinomycin D Protein Modification By Small Protein Conjugation Nuclear Body Response To Actinomycin D Nucleoplasm Cellular Response To UV-C Response To Gamma Radiation Protein Sumoylation Mitochondrial DNA Repair P53 Binding Protein Modification Process Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Telomere Maintenance Proteolysis Response To UV-C Protein Tag Activity Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Response To Ionizing Radiation Negative Regulation Of Proteolysis Response To UV Disordered Domain Specific Binding Cellular Response To Gamma Radiation Presynaptic Cytosol Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Radiation Postsynaptic Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of Programmed Necrotic Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
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