UBAC2 and GET4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		UBAC2	GET4
Description		UBA domain containing 2	guided entry of tail-anchored proteins factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protein Binding Protein-folding Chaperone Binding Protein Carrier Chaperone
	Biological Process	Wnt Signaling Pathway Protein Localization To Endoplasmic Reticulum Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Stability ERAD Pathway Maintenance Of Unfolded Protein Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Asthma ( 32296059 31959851 31619474 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Basal cell carcinoma ( 21700618) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cuneus cortex volume ( 31530798) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 28537254) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) Tinnitus ( 33742053)	PR interval ( 32439900)
Interacting Genes		5 interacting genes: CALCOCO2 GET4 LMO7 MIR182 UBC	29 interacting genes: AIRIM AKT1 ATP5PD CAPNS1 CDKN1A CEBPA CEP126 DUSP21 EEF1G ENKD1 FBN1 FBXO7 FLYWCH2 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2
Entrez ID		337867	51608
HPRD ID		11429	12909
Ensembl ID		ENSG00000134882	ENSG00000239857
Uniprot IDs		A8K2S7 Q8NBM4	Q7L5D6
PDB IDs			6AU8 7RU9 7RUA 7RUC
Enriched GO Terms of Interacting Partners?			Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Localization Response To Nutrient Levels Spindle Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Establishment Of Protein Localization To Organelle Carbohydrate Homeostasis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Microtubule-based Process Positive Regulation Of Protein Modification Process
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