HOXA2 and NDE1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		HOXA2	NDE1
Gene Name		homeobox A2	nudE neurodevelopment protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Kinetochore Condensed Chromosome Kinetochore Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Osteoblast Development Transcription, DNA-templated Segment Specification Motor Neuron Axon Guidance Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Rhombomere 2 Development Rhombomere 3 Morphogenesis Brain Segmentation Middle Ear Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Viscerocranium Morphogenesis Cellular Response To Retinoic Acid	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Organelle Organization Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Neuroblast Proliferation Cell Migration Cerebral Cortex Development Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization
Pathways			Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DMPK MEIS1 NDE1	27 interactors: AR ARNT2 BZRAP1 CDK1 DISC1 FAM9B GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 NDEL1 PAFAH1B1 REL TFIP11 TRIM27 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398
Entrez ID		3199	54820
HPRD ID		05252	14815
Ensembl ID		ENSG00000105996	ENSG00000072864
Uniprot IDs		O43364	Q9NXR1
PDB IDs
Enriched GO Terms of Interacting Partners?			Microtubule Cytoskeleton Organization Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Microtubule-based Process Nuclear Envelope Disassembly Cellular Localization Positive Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Establishment Of Mitotic Spindle Orientation Positive Regulation Of Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Mitotic Nuclear Division Positive Regulation Of Cellular Biosynthetic Process Retrograde Axon Cargo Transport Spindle Localization Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Nuclear Envelope Organization Regulation Of Cellular Localization Regulation Of Neurogenesis Organ Development Cell Proliferation Regulation Of Signaling Regulation Of Metabolic Process Establishment Of Localization In Cell Brain Development Cerebral Cortex Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Localization Head Development Mitotic Cell Cycle Phase Transition Telencephalon Cell Migration Cell Cycle Phase Transition Forebrain Cell Migration Regulation Of Cell Development Axonogenesis Positive Regulation Of Signal Transduction Regulation Of Neuron Differentiation Microtubule Organizing Center Organization Establishment Of Cell Polarity Positive Regulation Of Metabolic Process Microtubule Nucleation Axon Development Nervous System Development Nucleus Organization
Tagcloud ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain interacts ligase modes multitude pirh2 promotes proteasomal proteasome rchy1 regulators reports reveal stabilization subunits ubiquitin ubiquitination	breaks catastrophic cohesin completing concurrent discovered disorders ensures evoked fate genomic heterochromatin impediment indispensible integrity layer mid neural neurological pool progenitor progenitors remodeler replication restrictive safeguarding stalled steps strand
Tagcloud (Difference) ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain interacts ligase modes multitude pirh2 promotes proteasomal proteasome rchy1 regulators reports reveal stabilization subunits ubiquitin ubiquitination	breaks catastrophic cohesin completing concurrent discovered disorders ensures evoked fate genomic heterochromatin impediment indispensible integrity layer mid neural neurological pool progenitor progenitors remodeler replication restrictive safeguarding stalled steps strand
Tagcloud (Intersection) ?