APOF and RAG1

		APOF	RAG1
Description		apolipoprotein F	recombination activating 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Low-density Lipoprotein Particle High-density Lipoprotein Particle	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Cholesterol Binding	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endonuclease Activity
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Efflux	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Chromatin Organization Immune Response Visual Learning B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Regulation Of Behavioral Fear Response
Pathways		LDL remodeling	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Axial length ( 24144296) Blood protein levels ( 30072576)	Rheumatoid arthritis ( 24390342)
Interacting Genes		2 interacting genes: APOA1 APOA2	19 interacting genes: APP CDC34 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4C16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 TP53 UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		319	5896
HPRD ID		00137	01556
Ensembl ID		ENSG00000175336	ENSG00000166349
Uniprot IDs		Q13790	P15918
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Intestinal Cholesterol Absorption High-density Lipoprotein Particle Clearance Spherical High-density Lipoprotein Particle High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption High-density Lipoprotein Particle Binding Chylomicron Phospholipid Efflux Regulation Of Intestinal Absorption Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Phosphatidylcholine Biosynthetic Process Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Negative Regulation Of Cytokine Production Involved In Immune Response Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Cholesterol Binding Cellular Response To Amyloid-beta Phosphatidylcholine Metabolic Process Heat Shock Protein Binding Regulation Of Cholesterol Transport Response To Amyloid-beta Cholesterol Transport Positive Regulation Of Phagocytosis Sterol Transport Protein Homodimerization Activity Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Regulation Of Phagocytosis Cholesterol Metabolic Process Phospholipid Binding Blood Microparticle Sterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response	Chromatin Remodeling Chromatin Organization Ubiquitin Conjugating Enzyme Activity V(D)J Recombination Structural Constituent Of Chromatin Protein Heterodimerization Activity Protein K48-linked Ubiquitination Somatic Cell DNA Recombination Nucleosome Assembly RAGE Receptor Binding Nucleus Nucleosome Nucleoplasm Nucleosome Organization Molecular Function Activator Activity Protein-DNA Complex Assembly Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Chemoattractant Activity Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex Assembly Proteolysis Involved In Protein Catabolic Process Chromosome Supercoiled DNA Binding B Cell Lineage Commitment Protein Modification By Small Protein Conjugation Positive Chemotaxis Epigenetic Regulation Of Gene Expression Protein Polyubiquitination DNA Binding DNA Metabolic Process DNA Geometric Change Protein-containing Complex Cell Activation Involved In Immune Response Protein-containing Complex Organization DNA Topological Change NLS-dependent Protein Nuclear Import Complex Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Chromosome Organization Post-translational Protein Modification Catabolic Process Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Differentiation Regulation Of MiRNA Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?