KPNA5 and SPOPL

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KPNA5	SPOPL
Description		karyopherin subunit alpha 5	speckle type BTB/POZ protein like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex	Nucleus Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport	Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Hedgehog 'on' state
Drugs
Diseases
GWAS		Early cardiac repolarization ( 31600170) Telomere length ( 21460395)	Response to antipsychotic treatment ( 23241943)
Interacting Genes		29 interacting genes: ANP32A ANP32B ARNT ATM ATOSB BRMS1 CDKN1B CFTR DCPS EPAS1 FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326	6 interacting genes: ATF2 CREB5 EPS15 KPNA5 MYD88 RXRB
Entrez ID		3841	339745
HPRD ID		05179	11261
Ensembl ID		ENSG00000196911	ENSG00000144228
Uniprot IDs		A0A8V8TL88 A0A8V8TMV2 O15131	Q6IQ16
PDB IDs		4U2X
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Multicellular Organismal Process DNA Double-strand Break Processing Embryonic Placenta Development Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Apoptotic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Chromatin Negative Regulation Of Double-strand Break Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Repair MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Histone Deacetylase Binding Regulation Of Protein Modification Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Negative Regulation Of DNA Recombination Positive Regulation Of Hormone Biosynthetic Process DNA-binding Transcription Factor Activity	CAMP Response Element Binding Abducens Nucleus Development MRNA Transcription MRNA Transcription By RNA Polymerase II Hypoglossal Nucleus Development JNK Cascade Establishment Of Protein Localization To Organelle TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Organelle Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Import Into Nucleus Sequence-specific Double-stranded DNA Binding H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of DNA-binding Transcription Factor Activity Growth Plate Cartilage Chondrocyte Proliferation DNA-binding Transcription Factor Activity Protein Import Into Nucleus RNA Polymerase II Transcription Regulator Complex Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Identical Protein Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Positive Regulation Of RNA Metabolic Process Response To Molecule Of Fungal Origin Ubiquitin-dependent Endocytosis Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Toll-like Receptor Binding Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Brainstem Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
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