ITIH5 and PPM1D

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		ITIH5	PPM1D
Description		inter-alpha-trypsin inhibitor heavy chain 5	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Hyaluronan Metabolic Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction
Pathways			Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Left–right brain asymmetry ( 33723403) Metabolite levels ( 23823483) Planum temporale asymmetry index ( 31887566)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		10 interacting genes: BAG4 BRCA1 CHEK2 ESR2 HMMR NOTCH2 PPM1D RAD51 RB1CC1 XRCC3	25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		80760	8493
HPRD ID		13747	05482
Ensembl ID		ENSG00000123243	ENSG00000170836
Uniprot IDs		A0A096LP62 C9J2H1 G5E9D8 Q86UX2 Q96JW9	A0A0S2Z4M2 O15297
PDB IDs			8T2J
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Damage Checkpoint Regulation Of Intracellular Signal Transduction Nuclear Ubiquitin Ligase Complex Double-strand Break Repair Response To Glycoside Cellular Response To Ionizing Radiation Lateral Element Regulation Of Signal Transduction Telomere Maintenance Via Recombination Enzyme Binding DNA Damage Response Double-strand Break Repair Via Homologous Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Recombinational Repair Regulation Of Cell Communication Response To Radiation Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Signaling Cellular Response To Radiation Cellular Response To Gamma Radiation Chromosome, Telomeric Region DNA Repair Condensed Chromosome Homologous Recombination Interstrand Cross-link Repair DNA Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Centrosome Duplication Condensed Nuclear Chromosome Male Germ Cell Nucleus G2/M Transition Of Mitotic Cell Cycle Response To Gamma Radiation Response To Stress Cell Cycle G2/M Phase Transition Regulation Of Centrosome Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Response To Glucoside Negative Regulation Of MRNA Modification Ribophagy Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Regulation Of Programmed Cell Death Nucleus	Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding
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