LILRB2

Description		leukocyte immunoglobulin like receptor B2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Immune Response-regulating Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Learning Or Memory Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interleukin-10-mediated Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Postsynaptic Density Organization Negative Regulation Of T Cell Costimulation Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) HDL cholesterol ( 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lactate dehydrogenase levels ( 29403010) Nonsyndromic cleft lip ( 31609978)
Novel Interacting Genes		1 novel interacting genes: FDX1
Interacting Genes		7 interacting genes: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		10288
HPRD ID		11994
Ensembl ID		ENSG00000131042
Uniprot IDs		Q8N423
PDB IDs		2DYP 2GW5 4LLA 6AED 6BCS
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Positive Regulation Of Immune Effector Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity TAP Binding Early Endosome Membrane Phagocytic Vesicle Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Negative Regulation Of Defense Response Adaptive Immune Response Lymphocyte Mediated Immunity Regulation Of Cytokine Production Leukocyte Mediated Immunity Signaling Receptor Binding Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity
Tagcloud ?