HIC1 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
43

Data Source:
BioGRID (pull down)

		HIC1	CRBN
Description		HIC ZBTB transcriptional repressor 1	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development
Pathways		SUMOylation of transcription factors	Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)
Interacting Genes		12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I	47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2
Entrez ID		3090	51185
HPRD ID		04826	16750
Ensembl ID		ENSG00000177374	ENSG00000113851
Uniprot IDs		A0PJI1 Q14526	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transcription Corepressor Activity White Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway HLH Domain Binding Transcription Coregulator Binding Nuclear Receptor Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Modification Process Transcription Coactivator Activity Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Histone Deacetylase Activity Viral Genome Replication SUMO Transferase Activity Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels
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