ST6GALNAC6 and LRP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ST6GALNAC6	LRP10
Description		ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	LDL receptor related protein 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane Clathrin-coated Pit Membrane
	Molecular Function	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	Low-density Lipoprotein Particle Receptor Activity Protein Binding
	Biological Process	Ganglioside Biosynthetic Process Protein Glycosylation Lipid Metabolic Process Ceramide Metabolic Process Glycosylceramide Metabolic Process Glycosphingolipid Metabolic Process Glycosphingolipid Biosynthetic Process Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Cell-cell Recognition	Lipid Metabolic Process Lipid Transport Endocytosis Vesicle-mediated Transport Inner Ear Development
Pathways		Sialic acid metabolism Lewis blood group biosynthesis Glycosphingolipid biosynthesis	Retinoid metabolism and transport
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971)	Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Neutrophil count ( 32888494)
Interacting Genes		5 interacting genes: ANKRD46 APP ATXN1 ATXN1L LRP10	23 interacting genes: C16orf92 CISD2 EBP FAM209A GGA3 GJB5 GOLM2 GORAB HTRA1 LMNA MGST3 MRPS18B NOTO PDCD1LG2 PLEKHO1 SLC10A1 SLC14A2 SLC71A2 SMIM1 ST6GALNAC6 TMEM179B TMEM237 TMEM243
Entrez ID		30815	26020
HPRD ID		18111	14311
Ensembl ID		ENSG00000160408	ENSG00000197324
Uniprot IDs		A0A0S2Z5G9 B4DU80 F6SGE3 Q969X2	Q7Z4F1
PDB IDs
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Memory Learning Learning Or Memory Cognition Visual Learning Social Behavior Lung Alveolus Development Visual Behavior Clathrin-coated Pit Amyloid-beta Complex Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Associative Learning Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Locomotory Behavior Nervous System Process Regulation Of Spontaneous Synaptic Transmission Postsynapse Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Brain Development
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