ST6GALNAC6

Gene Name		ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Ganglioside Biosynthetic Process Dolichol-linked Oligosaccharide Biosynthetic Process Glycosylceramide Metabolic Process Glycosphingolipid Metabolic Process Glycoprotein Metabolic Process Oligosaccharide Biosynthetic Process Cell-cell Recognition Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: ATXN1 ATXN1L
Entrez ID		30815
HPRD ID		18111
Ensembl ID		ENSG00000160408
Uniprot IDs		Q969X2
PDB IDs
Enriched GO Terms of Interacting Partners?		Lung Alveolus Development Lung Development Respiratory Tube Development Respiratory System Development Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Tube Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Visual Learning Visual Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Proliferation Regulation Of Postsynaptic Membrane Potential Associative Learning Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Regulation Of Stem Cell Proliferation Adult Locomotory Behavior Membrane Depolarization Nuclear Export RNA Biosynthetic Process Learning Adult Behavior Organ Development
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