ST6GALNAC6 and ANKRD46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ST6GALNAC6	ANKRD46
Description		ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	ankyrin repeat domain 46
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane	Membrane
	Molecular Function	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	Protein Binding
	Biological Process	Ganglioside Biosynthetic Process Protein Glycosylation Lipid Metabolic Process Ceramide Metabolic Process Glycosylceramide Metabolic Process Glycosphingolipid Metabolic Process Glycosphingolipid Biosynthetic Process Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Cell-cell Recognition
Pathways		Sialic acid metabolism Lewis blood group biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971)	Atrioventricular conduction ( 21041692) Body mass index ( 26426971) Percentage gas trapping ( 26030696)
Interacting Genes		5 interacting genes: ANKRD46 APP ATXN1 ATXN1L LRP10	63 interacting genes: AMIGO1 APH1A AQP6 ARL13B BIK BSCL2 C16orf54 CD22 CD46 CLDN20 CLDN7 CLEC4D CRB3 CREB3L1 CXADR CYB561 EBP EFNB1 EFNB2 ELOVL4 FAM174A FAM209A FFAR2 GOLM1 GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IFNLR1 KASH5 KIR2DL3 LAMTOR5 LDLRAD1 LRRC25 MFF MMGT1 MUC1 NCAPH2 NSG2 PLPP4 PVR RELL2 RETREG3 SCN3B SECTM1 SHISA3 SLC10A6 SLC16A2 SLC18A1 SLC39A9 ST6GALNAC6 STX1A STX2 STX4 SUSD3 THAP4 TIMMDC1 TMEM248 TMEM31 TMEM45B TMEM79 TMPRSS2
Entrez ID		30815	157567
HPRD ID		18111	14103
Ensembl ID		ENSG00000160408	ENSG00000186106
Uniprot IDs		A0A0S2Z5G9 B4DU80 F6SGE3 Q969X2	B3KT99 Q86W74
PDB IDs
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Memory Learning Learning Or Memory Cognition Visual Learning Social Behavior Lung Alveolus Development Visual Behavior Clathrin-coated Pit Amyloid-beta Complex Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Associative Learning Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Locomotory Behavior Nervous System Process Regulation Of Spontaneous Synaptic Transmission Postsynapse Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Brain Development	Membrane Protein Binding Plasma Membrane Steroid Dehydrogenase Activity
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