HBM and HBD

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		HBM	HBD
Description		hemoglobin subunit mu	hemoglobin subunit delta
Image		No pdb structure
GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Oxygen Transport Erythrocyte Development	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glycated hemoglobin levels ( 31213470) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 28453575 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin levels ( 26366553) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 23263863)
Interacting Genes		6 interacting genes: HBB HBD HBE1 HBG2 HBZ VIRMA	6 interacting genes: APP HBA1 HBA2 HBM HBQ1 HBZ
Entrez ID		3042	3045
HPRD ID			00787
Ensembl ID		ENSG00000206177	ENSG00000223609
Uniprot IDs		Q6B0K9	A0N071 P02042
PDB IDs			1SHR 1SI4
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport Hemoglobin Alpha Binding One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Blood Microparticle Cell Development Cellular Developmental Process Haptoglobin Binding Nitric Oxide Transport Hemoglobin Binding Metal Ion Binding RNA N6-methyladenosine Methyltransferase Complex Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Erythrocyte Maturation Peroxidase Activity Hydrogen Peroxide Metabolic Process Developmental Process	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Myeloid Cell Development Oxygen Transport Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Cell Development Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport G Protein-coupled Receptor Binding Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Cellular Developmental Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Acetylcholine Receptor Activator Activity Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Blood Microparticle PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response
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