HIST1H2BD and HIRA

Number of citations of the paper that reports this interaction (PMID 9710638)
24

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIST1H2BD	HIRA
Gene Name		histone cluster 1, H2bd	histone cell cycle regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm PML Body Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	Chromatin Organization	Osteoblast Differentiation DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Anatomical Structure Morphogenesis Chromatin Modification Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: HIRA	15 interactors: ASF1A ASF1B CCNA2 CDK2 H3F3B HIRIP3 HIST1H2BD HIST1H2BK HIST2H2BE HNRNPD NFU1 PAX7 SUMO1 UBN1 UPF1
Entrez ID		3017	7290
HPRD ID		07535	02583
Ensembl ID		ENSG00000158373	ENSG00000100084
Uniprot IDs		P58876 P62807	P54198
PDB IDs			2I32
Enriched GO Terms of Interacting Partners?			Chromatin Organization Chromosome Organization Chromatin Assembly Or Disassembly DNA Replication-independent Nucleosome Assembly Nucleosome Assembly Organelle Organization Chromatin Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Packaging DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Chromatin Modification Cellular Macromolecular Complex Assembly Innate Immune Response In Mucosa Response To Stress Regulation Of Gene Silencing Cellular Response To DNA Damage Stimulus Antibacterial Humoral Response Regulation Of Gene Expression Antimicrobial Humoral Response Mucosal Immune Response Regulation Of Gene Expression, Epigenetic Protein Complex Assembly Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of RNA Metabolic Process Cellular Component Assembly Skeletal Muscle Satellite Cell Commitment Regulation Of Cellular Protein Metabolic Process Defense Response To Gram-positive Bacterium Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Mitotic DNA Integrity Checkpoint Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process PML Body Organization Positive Regulation Of DNA-dependent DNA Replication Initiation G2/M Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Localization To Nuclear Pore Positive Regulation Of Myoblast Proliferation
Tagcloud ?		circumstances complement cytoplasm display examining fraction hfob histone hmscs instead ionizing mesenchymal metazoan microarray mrnas osteoblast polyadenylated polyadenylation polyribosomes produce replication spliced transcripts transported tumorigenesis unlike varies	actively cabin1 caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Difference) ?		circumstances complement cytoplasm display examining fraction hfob histone hmscs instead ionizing mesenchymal metazoan microarray mrnas osteoblast polyadenylated polyadenylation polyribosomes produce replication spliced transcripts transported tumorigenesis unlike varies	actively cabin1 caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Intersection) ?