GZMA and PCP4

		GZMA	PCP4
Description		granzyme A	Purkinje cell protein 4
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Homodimerization Activity	Calcium Ion Binding Protein Binding Calmodulin Binding
	Biological Process	Proteolysis Apoptotic Process Immune Response Response To Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Positive Regulation Of Neuron Differentiation Positive Regulation Of CAMKK-AMPK Signaling Cascade
Pathways
Drugs
Diseases
GWAS			Asthma ( 32296059) Metabolite levels ( 23823483) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 12 weeks) ( 28437668)
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	7 interacting genes: CALM1 CALML6 DAPK1 PAX6 POT1 TERF1 TERF2IP
Entrez ID		3001	5121
HPRD ID		00771	03378
Ensembl ID		ENSG00000145649	ENSG00000183036
Uniprot IDs		P12544	P48539
PDB IDs		1OP8 1ORF	2N77
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Double-stranded Telomeric DNA Binding Double-stranded DNA Binding Damaged DNA Binding Chromosome Organization Chromatin Organization Structural Constituent Of Nuclear Lamina Telomere Maintenance Telomeric DNA Binding DNA End Binding Ku70:Ku80 Complex Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Nucleosome Assembly Protein-containing Complex Organization DNA Metabolic Process Telomere Organization DNA-dependent Protein Kinase Complex Nucleosome Organization Lamin Filament Nuclear Pore Localization Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Nuclear Telomere Cap Complex Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Chromosome Cellular Component Assembly Nuclear Lamina Protein Localization To Nuclear Envelope Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Protein-containing Complex Nucleus Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Biosynthetic Process Response To Salt Stress Nucleoplasm Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Endodeoxyribonuclease Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of DNA Metabolic Process Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Deoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly
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