HDC and DTX2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HDC	DTX2
Gene Name		histidine decarboxylase	deltex 2, E3 ubiquitin ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Histidine Decarboxylase Activity Pyridoxal Phosphate Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Histamine Biosynthetic Process Histidine Metabolic Process Histidine Catabolic Process Cellular Nitrogen Compound Metabolic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process	Notch Signaling Pathway Protein Ubiquitination
Pathways		Histidine catabolism Metabolism of amino acids and derivatives	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs		Pyridoxal Phosphate L-Histidine
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DTX2 GZMA	41 interactors: ABHD16A ALKBH4 ARNT2 C1orf94 DTX1 DTX3 EIF4ENIF1 FAM168A FHL2 GLYCTK GOLGA2 HDC HPCAL1 HPCAL4 KLC3 KRTAP26-1 MDC1 NCALD NCS1 NOTCH1 PLEKHF2 PLSCR1 QARS RBPMS RFX6 RHOXF2 RIMBP3 SEC22A SEC23B SPAG8 SPG21 STX12 SUMO1 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D3 UBE2D4 UBQLN4 VSNL1
Entrez ID		3067	113878
HPRD ID		00817	16841
Ensembl ID		ENSG00000140287	ENSG00000091073
Uniprot IDs		B7ZM01 P19113	Q86UW9
PDB IDs		4E1O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Nuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Oxidoreductase Activity Cytolysis Negative Regulation Of DNA Binding Regulation Of Oxidoreductase Activity Regulation Of DNA Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Binding Notch Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transcription, DNA-templated RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Innate Immune Response Protein K11-linked Ubiquitination RNA Metabolic Process Cellular Response To Oxygen Levels Heart Trabecula Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Hypoxia Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Notch Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Pancreatic Epsilon Cell Differentiation Glutaminyl-tRNA Aminoacylation Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Pancreatic D Cell Differentiation Cleavage Furrow Ingression Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Glandular Epithelial Cell Differentiation Signal Transduction Trabecula Morphogenesis Positive Regulation Of Innate Immune Response Vesicle Fusion Regulation Of Immune System Process Prolyl-tRNA Aminoacylation Vasculogenesis Involved In Coronary Vascular Morphogenesis Cardiac Right Atrium Morphogenesis Mitral Valve Formation Histamine Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		aspirated bdf1 cavity connective constructs cotransfection decarboxylase differentiate disappeared e2 fluid gata histidine humoral incubation inoculated intraperitoneal luciferase mafk markedly mast mmcp p45 p815 peritoneal proliferate protease syngenic transactivation	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Difference) ?		aspirated bdf1 cavity connective constructs cotransfection decarboxylase differentiate disappeared e2 fluid gata histidine humoral incubation inoculated intraperitoneal luciferase mafk markedly mast mmcp p45 p815 peritoneal proliferate protease syngenic transactivation	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Intersection) ?