SCHIP1 and NF2

Number of citations of the paper that reports this interaction (PMID 10669747)
15

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SCHIP1	NF2
Gene Name		schwannomin interacting protein 1	neurofibromin 2 (merlin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleolus Cytoplasm Early Endosome Cytoskeleton Plasma Membrane Adherens Junction Membrane Extrinsic Component Of Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Actin Binding Protein Binding
	Biological Process	Biological_process	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Lens Fiber Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Celiac disease ( 18311140) Major depressive disorder ( 23377640) Quantitative traits ( 19197348)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		7 interactors: FOS NF2 PSMD4 PTMS SCOC TMSB4X ZC3H13	24 interactors: AGAP2 AKT1 CCNB1IP1 CD44 CTNNB1 ERBB2 EZR HGS ITGB1 KDM1A MED28 PAK1 PXN PYGO2 RALGDS SCHIP1 SDCBP SGSM3 SLC9A3R1 SPTBN1 TARBP2 TSC1 VPRBP XPO1
Entrez ID		29970	4771
HPRD ID		15302	06980
Ensembl ID		ENSG00000151967	ENSG00000186575
Uniprot IDs		C9JWG6 Q9P0W5	P35240
PDB IDs			1H4R 3U8Z
Enriched GO Terms of Interacting Partners?			Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cell Development Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Cell Projection Organization Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Growth Factor Axon Guidance Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Anatomical Structure Development Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Localization Regulation Of Protein Kinase Activity Cell Morphogenesis Cell-matrix Adhesion Signal Transduction Nervous System Development Axonogenesis Cellular Response To Organic Substance Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Protein Localization Regulation Of Catalytic Activity Multicellular Organismal Development Developmental Process Cellular Localization Anatomical Structure Morphogenesis Axon Development Response To Stimulus Cellular Response To Growth Factor Stimulus
Tagcloud ?		11q23 3p14 3q25 6q21 ancestry associations atg5 comprising ddx6 dense dnase1l3 genotyped highlighted hla il12a immunochip imputed leukocyte loci overlooked pleiotropic polymorphic positions pxk reaching refined snps ssc treh	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Difference) ?		11q23 3p14 3q25 6q21 ancestry associations atg5 comprising ddx6 dense dnase1l3 genotyped highlighted hla il12a immunochip imputed leukocyte loci overlooked pleiotropic polymorphic positions pxk reaching refined snps ssc treh	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Intersection) ?