NMRK2 and IGF2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NMRK2	IGF2
Description		nicotinamide riboside kinase 2	insulin like growth factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Nicotinate Riboside Kinase Activity Metal Ion Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	NADP+ Biosynthetic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process NAD+ Biosynthetic Process Via The Salvage Pathway Negative Regulation Of Myoblast Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Nicotinate metabolism	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases			Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Leukocyte telomere length ( 32109421)	Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926 32499647) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: APP CDKN1A IGF2 ITGB1 LRP12 SAT1	26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN
Entrez ID		27231	3481
HPRD ID		16371	00939
Ensembl ID		ENSG00000077009	ENSG00000167244
Uniprot IDs		Q9NPI5	E3UN46 P01344
PDB IDs			1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC
Enriched GO Terms of Interacting Partners?		Integrin Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Cell Population Proliferation Regulation Of Growth Insulin Receptor Binding Molecular Function Activator Activity Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Immune System Process Amyloid-beta Complex Developmental Growth Growth Cone Lamellipodium Synaptic Membrane Response To Light Stimulus Positive Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Clathrin-coated Pit Positive Regulation Of Multicellular Organismal Process Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Population Proliferation Striated Muscle Cell Differentiation Myoblast Fate Specification Integrin Alpha7-beta1 Complex Spermidine Binding Regulation Of Cell Cycle Acetylcholine Receptor Activator Activity Response To Interleukin-1 Associative Learning Neuron Projection Development Positive Regulation Of Intracellular Signal Transduction Endocytosis Lipoprotein Particle Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Import Response To Radiation Protein Kinase Binding	Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?