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NMRK2 and IGF2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
NMRK2
IGF2
Gene Name
nicotinamide riboside kinase 2
insulin-like growth factor 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Extracellular Region
Extracellular Space
Plasma Membrane
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
ATP Binding
Metal Ion Binding
Ribosylnicotinamide Kinase Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Receptor Activator Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
NAD Biosynthetic Process
Phosphorylation
Negative Regulation Of Myoblast Differentiation
Skeletal System Development
Osteoblast Differentiation
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Glucose Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Female Pregnancy
Blood Coagulation
Memory
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Response To Radiation
Organ Morphogenesis
Platelet Activation
Exocrine Pancreas Development
Response To Nutrient Levels
Response To Estradiol
Response To Nicotine
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Positive Regulation Of Activated T Cell Proliferation
Response To Drug
Positive Regulation Of Catalytic Activity
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Response To Ethanol
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Mechanical Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Steroid Hormone Biosynthetic Process
Positive Regulation Of Receptor Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
IRS-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Response to elevated platelet cytosolic Ca2+
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
SHC-related events triggered by IGF1R
Platelet degranulation
Platelet activation, signaling and aggregation
IGF1R signaling cascade
Drugs
Diseases
GWAS
DNA methylation (variation) (
23725790
)
Femoral neck bone geometry and menarche (age at onset) (
23593202
)
Prostate cancer (
19767753
)
Protein-Protein Interactions
7 interactors:
APP
CDKN1A
IGF2
ITGB1
LRP12
SAT1
ST7
22 interactors:
BAG6
FAF1
GPC3
IDE
IGF1R
IGF2R
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
INSR
NMRK2
NOV
PCSK4
PLG
RBPMS
TF
VTN
WISP2
Entrez ID
27231
3481
HPRD ID
16371
00939
Ensembl ID
ENSG00000077009
ENSG00000167244
Uniprot IDs
B7ZKR3
Q9NPI5
P01344
PDB IDs
1GF2
1IGL
2L29
2V5P
3E4Z
3KR3
Enriched GO Terms of Interacting Partners
?
Response To Radiation
Regulation Of Growth
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Cycle Process
Learning Or Memory
Signaling
Cell Communication
Positive Regulation Of Cell Cycle
Cognition
Regulation Of Cell Cycle
Response To Light Stimulus
Cellular Response To Ionizing Radiation
Visual Learning
Regulation Of Protein Phosphorylation
Visual Behavior
Cellular Response To Stimulus
Response To Abiotic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Mechanical Stimulus
Regulation Of Mitotic Cell Cycle
Platelet Degranulation
Blood Coagulation
Hemostasis
Associative Learning
Positive Regulation Of Protein Metabolic Process
Single-organism Behavior
Developmental Cell Growth
Response To Extracellular Stimulus
Regulation Of Phosphorylation
Regulation Of Cell Cycle Process
Regulation Of Cellular Ketone Metabolic Process
Response To Drug
Vesicle-mediated Transport
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Proliferation
Regulation Of Body Fluid Levels
Positive Regulation Of Lymphocyte Proliferation
Transport
Behavior
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Receptor Activity
Wound Healing
Spermidine Acetylation
Synaptic Growth At Neuromuscular Junction
Response To Stimulus
Learning
Cellular Response To Radiation
Signal Transduction
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Growth
Regulation Of Cellular Component Organization
Regulation Of Cell Growth
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Type B Pancreatic Cell Proliferation
Regulation Of Cell Proliferation
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Developmental Process
Regulation Of Signal Transduction
Regulation Of Glucose Metabolic Process
Regulation Of Signaling
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phosphorylation
Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Insulin Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Regulation Of Carbohydrate Metabolic Process
Regulation Of Cell Migration
Regulation Of Phosphorylation
Reproductive Process
Regulation Of Cell Motility
Exocrine Pancreas Development
Exocrine System Development
Cellular Protein Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Insulin Stimulus
Response To Stimulus
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Organonitrogen Compound
Regulation Of Cellular Process
Male Sex Determination
Anatomical Structure Development
Tissue Development
Negative Regulation Of Smooth Muscle Cell Migration
Protein Tetramerization
Response To Insulin
Response To Hormone
Insulin-like Growth Factor Receptor Signaling Pathway
Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Regulation Of Protein Kinase B Signaling
Tagcloud
?
affects
biological
blast
carrying
cdna
cecum
crossed
deleted
disrupted
excess
exclusively
igf2r
involve
mannose
must
organ
organs
overexpressing
paternal
phenotypes
proteolytic
sdeltaigf2r
sigf2r
slow
solely
soluble
stomach
transgenics
transmembrane
Tagcloud (Difference)
?
affects
biological
blast
carrying
cdna
cecum
crossed
deleted
disrupted
excess
exclusively
igf2r
involve
mannose
must
organ
organs
overexpressing
paternal
phenotypes
proteolytic
sdeltaigf2r
sigf2r
slow
solely
soluble
stomach
transgenics
transmembrane
Tagcloud (Intersection)
?